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• W1978352011 startingPage "921" @default.
• W1978352011 abstract "The refined crystal structure of the ternary complex of yeast Phe-tRNAPhe, Thermus aquaticus elongation factor EF-Tu and the non-hydrolyzable GTP analog, GDPNP, reveals many details of the EF-Tu recognition of aminoacylated tRNA (aa-tRNA). EF-Tu-GTP recognizes the aminoacyl bond and one side of the backbone fold of the acceptor helix and has a high affinity for all ordinary elongator aa-tRNAs by binding to this aa-tRNA motif. Yet, the binding of deacylated tRNA, initiator tRNA, and selenocysteine-specific tRNA (tRNASec) is effectively discriminated against. Subtle rearrangements of the binding pocket may occur to optimize the fit to any side chain of the aminoacyl group and interactions with EF-Tu stabilize the 3'-aminoacyl isomer of aa-tRNA. A general complementarity is observed in the location of the binding sites in tRNA for synthetases and for EF-Tu. The complex formation is highly specific for the GTP-bound conformation of EF-Tu, which can explain the effects of various mutants." @default.
• W1978352011 created "2016-06-24" @default.
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• W1978352011 date "1996-01-01" @default.
• W1978352011 modified "2023-09-23" @default.
• W1978352011 title "The ternary complex of aminoacylated tRNA and EF-Tu-GTP. Recognition of a bond and a fold" @default.
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• W1978352011 doi "https://doi.org/10.1016/s0300-9084(97)86714-4" @default.
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• W1978352011 hasPublicationYear "1996" @default.
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