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- W1978355305 abstract "The transcription factor NF-ATc is synthesized in three prominent isoforms. These differ in the length of their C terminal peptides and mode of synthesis. Due to a switch from the use of a 3' polyA site to a more proximal polyA site, NF-ATc expression switches from the synthesis of the two longer isoforms in naive T cells to that of short isoform A in T effector cells. The relative low binding affinity of cleavage stimulation factor CstF-64 to the proximal polyA site seems to contribute to its neglect in naive T cells. These alternative polyadenylation events ensure the rapid accumulation of high concentrations of NF-ATc necessary to exceed critical threshold levels of NF-ATc for gene induction in effector T cells." @default.
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- W1978355305 date "1999-02-01" @default.
- W1978355305 modified "2023-10-11" @default.
- W1978355305 title "Alternative Polyadenylation Events Contribute to the Induction of NF-ATc in Effector T Cells" @default.
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- W1978355305 doi "https://doi.org/10.1016/s1074-7613(00)80026-6" @default.
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