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- W1978355655 abstract "Abstract N ‐Acyl‐phosphatidylethanolamine (NAPE) is present in very small amounts in mammalian tissues (less than 0.1% of total phospholipids). However, NAPE as well as its degradation product, N ‐acylethanolamine (NAE), can be formed in certain neuronal tissues in response to increased [Ca 2+ ] i . A high [Ca 2+ ] i will activate the NAPE‐forming N ‐acyl‐transferase using the sn ‐1 acyl group of a donor phospholipid as substrate in the transfer reaction. This membrane‐bound enzyme seems to have no substrate specificity with respect to transfer of acyl groups; thus the fatty acids in the N ‐acyl group of NAPE are mainly 16:0 and 18:1, corresponding to the fatty acids in the sn ‐1 acyl group of the donor phospholipids. The NAPE‐hydrolyzing phospholipase D also seems not to be acyl‐group specific. In mouse neocortical neurons in primary culture, formation of NAPE and NAE is stimulated by glutamate via activation of the N ‐methyl‐ d ‐aspartate‐receptor. Both NAPE and, to a lesser extent, NAE accumulate in a linear fashion for many hours while at the same time the neurons are dying. Likewise, in neurons prelabeled with 14 C‐arachidonic acid, 14 C‐arachidonic acid‐labeled NAPE, and anandamide (= N ‐arachi‐donoylethanolamine) are accumulating. The formation of NAPE and NAE may represent a cytoprotective response in relation to various forms of neurotoxicity." @default.
- W1978355655 created "2016-06-24" @default.
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- W1978355655 date "1999-01-01" @default.
- W1978355655 modified "2023-10-05" @default.
- W1978355655 title "Formation of<i>N</i>‐acyl‐phosphatidylethanolamine and<i>N</i>‐acylethanolamine (including anandamide) during glutamate‐induced neurotoxicity" @default.
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