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- W1978360377 abstract "The purpose of this study was to examine the effect of Δ9-tetrahydrocannabinol (Δ9-THC), the major psychoactive component of marijuana, on T lymphocyte functional competence against herpes simplex virus Type 1 (HSV1) infection. Spleen cells from C3H/HeJ (H-2k) mice primed with HSV1 and exposed to Δ9-THC were examined for anti- HSV1 cytolytic T lymphocyte (CTL) activity. Flow cytometry was used to determine whether Δ9-THC altered T cytotoxic (Lyt-2+) and T helper (L3T4+) lymphocyte numbers or cell ratios. Nomarski optics microscopy was used to determine whether effector lymphocytes from drug-treated mice were able to bind to virally infected L929 (H-2k) target cells. Cytotoxicity assays demonstrated that CTL from mice exposed to Δ9-THC were deficient in anti-HSV1 cytolytic activity. Δ9-THC in vivo treatment had little effect on the number of T lymphocytes expressing the Lyt-2 or L3T4 antigens. Nomarski optics microscopy revealed that the CTL from the drug-treated mice were able to bind specifically to the HSV1-infected targets. However, Δ9-THC In vivo exposure affected CTL cytoplasmic polarization toward the virus-infected target cell. CTL granule reorientation toward the effector cell-target cell interface following cell conjugation occurred at a lower frequency in co-cultures containing CTL from drug-treated mice. These results suggest that Δ9-THC elicits dysfunction in CTL by altering effector cell-target cell postconjugation events." @default.
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- W1978360377 date "1992-07-01" @default.
- W1978360377 modified "2023-09-26" @default.
- W1978360377 title " 9-Tetrahydrocannabinol Decreases Cytotoxic T Lymphocyte Activity to Herpes Simplex Virus Type 1-Infected Cells" @default.
- W1978360377 doi "https://doi.org/10.3181/00379727-200-43452" @default.
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