FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978360972> ?p ?o ?g. }

• W1978360972 endingPage "435" @default.
• W1978360972 startingPage "425" @default.
• W1978360972 abstract "The mechanism (both at the whole body and cellular level) by which metformin improves insulin sensitivity has yet to be defined. In the present study, we examined in vivo insulin-mediated whole-body glucose disposal, glycogen synthesis, hepatic glucose production, and insulin secretion, as well as in vitro muscle insulin receptor tyrosine kinase activity in eight control, eight neonatal streptozotocin diabetic rats, and eight diabetic rats before and after treatment with metformin. Ten weeks after birth diabetic rats had higher fasting (132 + 5 v 101 + 2 mg/dL) and postmeal (231 + 10 v 133 + 3) plasma glucose levels compared with controls (P less than .001). Metformin treatment was followed by a significant decrease in the growth rate and normalized glucose tolerance without enhancing the deficient insulin response. Insulin-mediated glucose uptake in diabetic versus control rats was reduced (P less than .01) during the high-dose (15.4 + 0.6 v 18.3 + 1.0 mg/kg.min) insulin clamp study and was increased to values greater (P less than .05) than controls following metformin treatment. Muscle glycogen synthetic rate in vivo, measured by incorporation of 3H-3-glucose radioactivity, was diminished by 25% (P less than .01) in diabetic rats, restored to normal values with metformin, and correlated closely (r = .82, P less than .002) with total-body glucose uptake during the insulin clamp in all three groups. Insulin receptor tyrosine kinase activity, measured in partially purified insulin receptors, was reduced in diabetic rats and increased to supernormal levels after metformin. The decrease in muscle tyrosine kinase activity in diabetic versus control animals was entirely accounted for by a reduction in maximal velocity (Vmax) (32 v 45 pmol/mg.min, P less than .01) and increased to supernormal levels following metformin (91 pmol/mg.min, P less than .001) without any change in affinity (Km). Muscle tyrosine kinase activity was closely correlated with both the muscle glycogen synthetic rate (r = .82, P less than .002) and total-body insulin-mediated glucose disposal (r = .64, P less than .01) in vivo. The close correlation between in vivo insulin action, muscle glycogen synthesis, and muscle insulin receptor tyrosine kinase activity is consistent with an important role of the enzyme in the insulin resistance of diabetes and its improvement following metformin treatment." @default.
• W1978360972 created "2016-06-24" @default.
• W1978360972 creator A5004383719 @default.
• W1978360972 creator A5008465775 @default.
• W1978360972 creator A5027916227 @default.
• W1978360972 creator A5043831622 @default.
• W1978360972 creator A5045849922 @default.
• W1978360972 creator A5063552809 @default.
• W1978360972 creator A5074852816 @default.
• W1978360972 creator A5076650236 @default.
• W1978360972 creator A5091912602 @default.
• W1978360972 date "1990-04-01" @default.
• W1978360972 modified "2023-09-28" @default.
• W1978360972 title "Effect of metformin treatment on insulin action in diabetic rats: In vivo and in vitro correlations" @default.
• W1978360972 cites W1515298003 @default.
• W1978360972 cites W1533778697 @default.
• W1978360972 cites W1563608944 @default.
• W1978360972 cites W1577741430 @default.
• W1978360972 cites W1591826165 @default.
• W1978360972 cites W189341708 @default.
• W1978360972 cites W1965289437 @default.
• W1978360972 cites W1970116744 @default.
• W1978360972 cites W1974540301 @default.
• W1978360972 cites W1982935454 @default.
• W1978360972 cites W1983498402 @default.
• W1978360972 cites W1983649348 @default.
• W1978360972 cites W1986015138 @default.
• W1978360972 cites W1986955391 @default.
• W1978360972 cites W2001399358 @default.
• W1978360972 cites W2017530885 @default.
• W1978360972 cites W2021331727 @default.
• W1978360972 cites W2023056644 @default.
• W1978360972 cites W2030156849 @default.
• W1978360972 cites W2031058311 @default.
• W1978360972 cites W2036227669 @default.
• W1978360972 cites W2037645878 @default.
• W1978360972 cites W2048891135 @default.
• W1978360972 cites W2056925433 @default.
• W1978360972 cites W2057231488 @default.
• W1978360972 cites W2062299625 @default.
• W1978360972 cites W2067691245 @default.
• W1978360972 cites W2067772915 @default.
• W1978360972 cites W2067901605 @default.
• W1978360972 cites W2072591785 @default.
• W1978360972 cites W2077020659 @default.
• W1978360972 cites W2079132312 @default.
• W1978360972 cites W2081914116 @default.
• W1978360972 cites W2081915831 @default.
• W1978360972 cites W2084730744 @default.
• W1978360972 cites W2089474285 @default.
• W1978360972 cites W2090921817 @default.
• W1978360972 cites W2096329362 @default.
• W1978360972 cites W2097063465 @default.
• W1978360972 cites W2099469518 @default.
• W1978360972 cites W2104713078 @default.
• W1978360972 cites W2104934821 @default.
• W1978360972 cites W2120073172 @default.
• W1978360972 cites W2152677046 @default.
• W1978360972 cites W2153131519 @default.
• W1978360972 cites W2153868682 @default.
• W1978360972 cites W2162898930 @default.
• W1978360972 cites W2163499850 @default.
• W1978360972 cites W2169226001 @default.
• W1978360972 cites W2169401893 @default.
• W1978360972 cites W222942812 @default.
• W1978360972 cites W2292274763 @default.
• W1978360972 cites W2977031313 @default.
• W1978360972 doi "https://doi.org/10.1016/0026-0495(90)90259-f" @default.
• W1978360972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2157941" @default.
• W1978360972 hasPublicationYear "1990" @default.
• W1978360972 type Work @default.
• W1978360972 sameAs 1978360972 @default.
• W1978360972 citedByCount "102" @default.
• W1978360972 countsByYear W19783609722012 @default.
• W1978360972 countsByYear W19783609722014 @default.
• W1978360972 countsByYear W19783609722015 @default.
• W1978360972 countsByYear W19783609722016 @default.
• W1978360972 countsByYear W19783609722017 @default.
• W1978360972 countsByYear W19783609722018 @default.
• W1978360972 countsByYear W19783609722019 @default.
• W1978360972 countsByYear W19783609722020 @default.
• W1978360972 countsByYear W19783609722021 @default.
• W1978360972 countsByYear W19783609722022 @default.
• W1978360972 crossrefType "journal-article" @default.
• W1978360972 hasAuthorship W1978360972A5004383719 @default.
• W1978360972 hasAuthorship W1978360972A5008465775 @default.
• W1978360972 hasAuthorship W1978360972A5027916227 @default.
• W1978360972 hasAuthorship W1978360972A5043831622 @default.
• W1978360972 hasAuthorship W1978360972A5045849922 @default.
• W1978360972 hasAuthorship W1978360972A5063552809 @default.
• W1978360972 hasAuthorship W1978360972A5074852816 @default.
• W1978360972 hasAuthorship W1978360972A5076650236 @default.
• W1978360972 hasAuthorship W1978360972A5091912602 @default.
• W1978360972 hasBestOaLocation W19783609721 @default.
• W1978360972 hasConcept C112446052 @default.
• W1978360972 hasConcept C126322002 @default.
• W1978360972 hasConcept C134018914 @default.
• W1978360972 hasConcept C150903083 @default.

• next