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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978361373> ?p ?o ?g. }

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• W1978361373 abstract "The NOD-derived islet-reactive CD4(+) T cell clone, BDC-2.5, is able to transfer diabetes to neonatal non-obese diabetic (NOD) mice but is unable to transfer disease to either adult NOD or NOD scid recipients. Transfer of diabetes to adult recipients by BDC-2.5 is only accomplished by cotransfer of CD8(+) T cells from a diabetic donor. To understand why this CD4(+) T cell clone is able to mediate diabetes in neonatal but not the adult recipients we examined the ability of the clone to traffic in the different recipients. Our studies showed that MAdCAM-1 has a very different expression pattern in the neonatal and adult pancreas. Blockade of this addressin prevents the clone from transferring diabetes to neonatal mice, suggesting that the differential pancreatic expression of MAdCAM-1 in neonatal and adult pancreas provides an explanation of the differences in diabetes development." @default.
• W1978361373 created "2016-06-24" @default.
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• W1978361373 date "2005-10-07" @default.
• W1978361373 modified "2023-10-15" @default.
• W1978361373 title "MAdCAM-1 is needed for diabetes development mediated by the T cell clone, BDC-2.5" @default.
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• W1978361373 doi "https://doi.org/10.1111/j.1365-2567.2005.02254.x" @default.
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