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- W1978364689 abstract "The pyranoacridone alkaloid acronycine (1), originally isolated from Acronychia baueri Schott (Rutaceae), has shown interesting properties against solid tumors. Significant improvements in terms of solubility and potency were obtained with derivatives modified in the pyran ring, such as diesters of cis-1,2-dihydroxy-1,2-dihydroacronycine (2) and cis-1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine (3). Their mechanism of action implies alkylation of the 2-amino group of DNA guanine residues by the carbocation resulting from the elimination of the ester leaving group at position 1 of the drug." @default.
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- W1978364689 date "2008-07-01" @default.
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- W1978364689 title "Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring" @default.
- W1978364689 doi "https://doi.org/10.1055/s-0028-1084761" @default.
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