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- W1978367405 abstract "Regarding the duration of therapy, application of amiodarone to the fetus is a short-term treatment, since in the majority of infants SVT can be treated effectively with other drugs after birth. Because there was no data available concerning intravascular injection of amiodarone in the fetus, we initially selected a dose of 10 mg (estimated weight of fetus 1000 pm), then increased the dosage to 20 mg, and finally to 40 mg. Compared with bolus injections, the selected doses were high. Inasmuch as no unwanted effects were observed, the doses were increased to avoid numerous punctures of the umbilical vein. With this regimen no negative effects on sinus rhythm or cardiac performance were observed. The following conclusions were drawn: (1) fetal and maternal drug levels are documented to be different depending on the degree of hydrops fetalis. Based on these experiences direct applications of antiarrhythmic drugs can be necessary in fetuses with severe hydrops caused by tachyarrhythmia when hampered transplacental passage of antiarrhythmic drugs is proved by sampling of fetal blood. (2) Repeated umbilical puncture is safe for direct infusion of drug. (3) Amiodarone is effective without side effects in the fetus; therefore amiodarone could become the drug of choice for direct treatment of the fetus in rare, otherwise drug-refractory cases. However, further experience with dose selection and drug safety is required." @default.
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- W1978367405 date "1989-12-01" @default.
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- W1978367405 title "Concordant total anomalous pulmonary venous connection in dizygotic twins" @default.
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- W1978367405 doi "https://doi.org/10.1016/0002-8703(89)90029-x" @default.
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