FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978370367> ?p ?o ?g. }

• W1978370367 endingPage "14455" @default.
• W1978370367 startingPage "14452" @default.
• W1978370367 abstract "Dominant negative inhibition is most commonly seen when a mutant subunit of a multisubunit protein is coexpressed with the wild-type protein so that assembly of a functional oligomer is impaired. By analogy, it should be possible to interfere with the functional assembly of a monomeric enzyme by interfering with the folding pathway. Experiments in vitro by others suggested that fragments of a monomeric enzyme might be exploited for this purpose. We report here dominant negative inhibition of bacterial cell growth by expression of fragments of a tRNA synthetase. Inhibition is fragment-specific, as not all fragments cause inhibition. An inhibitory fragment characterized in more detail forms a specific complex with the intact enzyme in vivo , leading to enzyme inactivation. This fragment also associated stoichiometrically with the full-length enzyme in vitro after denaturation and refolding, and the resulting complex was catalytically inactive. Inhibition therefore appears to arise from an interruption in the folding pathway of the wild-type enzyme, thus suggesting a new strategy to design dominant negative inhibitors of monomeric enzymes." @default.
• W1978370367 created "2016-06-24" @default.
• W1978370367 creator A5025816952 @default.
• W1978370367 creator A5026856074 @default.
• W1978370367 creator A5050315454 @default.
• W1978370367 creator A5075255077 @default.
• W1978370367 date "1996-12-10" @default.
• W1978370367 modified "2023-10-14" @default.
• W1978370367 title "Dominant negative inhibition by fragments of a monomeric enzyme" @default.
• W1978370367 cites W1571547690 @default.
• W1978370367 cites W1633739406 @default.
• W1978370367 cites W1647761057 @default.
• W1978370367 cites W1767560565 @default.
• W1978370367 cites W1982708002 @default.
• W1978370367 cites W1988981438 @default.
• W1978370367 cites W1991923790 @default.
• W1978370367 cites W1992401304 @default.
• W1978370367 cites W1994738496 @default.
• W1978370367 cites W1999200731 @default.
• W1978370367 cites W2003796534 @default.
• W1978370367 cites W2005288455 @default.
• W1978370367 cites W2007129064 @default.
• W1978370367 cites W2011769650 @default.
• W1978370367 cites W2012163065 @default.
• W1978370367 cites W2021731125 @default.
• W1978370367 cites W2029474258 @default.
• W1978370367 cites W2032345748 @default.
• W1978370367 cites W2054968530 @default.
• W1978370367 cites W2062223397 @default.
• W1978370367 cites W2067680630 @default.
• W1978370367 cites W2072702103 @default.
• W1978370367 cites W2081663482 @default.
• W1978370367 cites W2088639365 @default.
• W1978370367 cites W2089119659 @default.
• W1978370367 cites W2092875598 @default.
• W1978370367 cites W2125423296 @default.
• W1978370367 cites W4247052642 @default.
• W1978370367 doi "https://doi.org/10.1073/pnas.93.25.14452" @default.
• W1978370367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/26153" @default.
• W1978370367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8962072" @default.
• W1978370367 hasPublicationYear "1996" @default.
• W1978370367 type Work @default.
• W1978370367 sameAs 1978370367 @default.
• W1978370367 citedByCount "18" @default.
• W1978370367 countsByYear W19783703672015 @default.
• W1978370367 countsByYear W19783703672017 @default.
• W1978370367 countsByYear W19783703672018 @default.
• W1978370367 countsByYear W19783703672019 @default.
• W1978370367 countsByYear W19783703672022 @default.
• W1978370367 crossrefType "journal-article" @default.
• W1978370367 hasAuthorship W1978370367A5025816952 @default.
• W1978370367 hasAuthorship W1978370367A5026856074 @default.
• W1978370367 hasAuthorship W1978370367A5050315454 @default.
• W1978370367 hasAuthorship W1978370367A5075255077 @default.
• W1978370367 hasBestOaLocation W19783703672 @default.
• W1978370367 hasConcept C104292427 @default.
• W1978370367 hasConcept C104317684 @default.
• W1978370367 hasConcept C119599485 @default.
• W1978370367 hasConcept C125209161 @default.
• W1978370367 hasConcept C127413603 @default.
• W1978370367 hasConcept C13965031 @default.
• W1978370367 hasConcept C143065580 @default.
• W1978370367 hasConcept C153911025 @default.
• W1978370367 hasConcept C181199279 @default.
• W1978370367 hasConcept C185592680 @default.
• W1978370367 hasConcept C202751555 @default.
• W1978370367 hasConcept C204328495 @default.
• W1978370367 hasConcept C2776545253 @default.
• W1978370367 hasConcept C2776923230 @default.
• W1978370367 hasConcept C55493867 @default.
• W1978370367 hasConcept C7927669 @default.
• W1978370367 hasConcept C86803240 @default.
• W1978370367 hasConceptScore W1978370367C104292427 @default.
• W1978370367 hasConceptScore W1978370367C104317684 @default.
• W1978370367 hasConceptScore W1978370367C119599485 @default.
• W1978370367 hasConceptScore W1978370367C125209161 @default.
• W1978370367 hasConceptScore W1978370367C127413603 @default.
• W1978370367 hasConceptScore W1978370367C13965031 @default.
• W1978370367 hasConceptScore W1978370367C143065580 @default.
• W1978370367 hasConceptScore W1978370367C153911025 @default.
• W1978370367 hasConceptScore W1978370367C181199279 @default.
• W1978370367 hasConceptScore W1978370367C185592680 @default.
• W1978370367 hasConceptScore W1978370367C202751555 @default.
• W1978370367 hasConceptScore W1978370367C204328495 @default.
• W1978370367 hasConceptScore W1978370367C2776545253 @default.
• W1978370367 hasConceptScore W1978370367C2776923230 @default.
• W1978370367 hasConceptScore W1978370367C55493867 @default.
• W1978370367 hasConceptScore W1978370367C7927669 @default.
• W1978370367 hasConceptScore W1978370367C86803240 @default.
• W1978370367 hasIssue "25" @default.
• W1978370367 hasLocation W19783703671 @default.
• W1978370367 hasLocation W19783703672 @default.
• W1978370367 hasLocation W19783703673 @default.
• W1978370367 hasLocation W19783703674 @default.
• W1978370367 hasOpenAccess W1978370367 @default.
• W1978370367 hasPrimaryLocation W19783703671 @default.
• W1978370367 hasRelatedWork W1508745139 @default.
• W1978370367 hasRelatedWork W1550996414 @default.

• next