FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978370935> ?p ?o ?g. }

• W1978370935 endingPage "127" @default.
• W1978370935 startingPage "119" @default.
• W1978370935 abstract "Abstract Background: The lung cancer risk of smokers varies by race/ethnicity even after adjustment for smoking. Evaluating the role of genetics in nicotine metabolism is likely important in understanding these differences, as disparities in risk may be related to differences in nicotine dose and metabolism. Methods: We conducted a genome-wide association study in search of common genetic variants that predict nicotine and cotinine glucuronidation in a sample of 2,239 smokers (437 European Americans, 364 African Americans, 453 Latinos, 674 Japanese Americans, and 311 Native Hawaiians) in the Multiethnic Cohort Study. Urinary concentration of nicotine and its metabolites were determined. Results: Among 11,892,802 variants analyzed, 1,241 were strongly associated with cotinine glucuronidation, 490 of which were also associated with nicotine glucuronidation (P &lt; 5×10−8). The vast majority were within chromosomal region 4q13, near UGT2B10. Fifteen independent and globally significant SNPs explained 33.2% of the variation in cotinine glucuronidation, ranging from 55% for African Americans to 19% for Japanese Americans. The strongest single SNP association was for rs115765562 (P = 1.60 × 10−155). This SNP is highly correlated with a UGT2B10 splice site variant, rs116294140, which together with rs6175900 (Asp67Tyr) explains 24.3% of the variation. The top SNP for nicotine glucuronidation (rs116224959, P = 2.56 × 10−43) was in high LD (r2 = 0.99) with rs115765562. Conclusions: Genetic variation in UGT2B10 contributes significantly to nicotine and cotinine glucuronidation but not to nicotine dose. Impact: The contribution of genetic variation to nicotine and cotinine glucuronidation varies significantly by racial/ethnic group, but is unlikely to contribute directly to lung cancer risk. Cancer Epidemiol Biomarkers Prev; 24(1); 119–27. ©2014 AACR." @default.
• W1978370935 created "2016-06-24" @default.
• W1978370935 creator A5013179873 @default.
• W1978370935 creator A5016405051 @default.
• W1978370935 creator A5022126431 @default.
• W1978370935 creator A5037748128 @default.
• W1978370935 creator A5046710077 @default.
• W1978370935 creator A5053074659 @default.
• W1978370935 creator A5063065323 @default.
• W1978370935 creator A5063459619 @default.
• W1978370935 date "2015-01-01" @default.
• W1978370935 modified "2023-10-15" @default.
• W1978370935 title "The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations" @default.
• W1978370935 cites W1968984630 @default.
• W1978370935 cites W1974578491 @default.
• W1978370935 cites W1977634870 @default.
• W1978370935 cites W1982969180 @default.
• W1978370935 cites W1983906278 @default.
• W1978370935 cites W1987754412 @default.
• W1978370935 cites W1992436001 @default.
• W1978370935 cites W1997828131 @default.
• W1978370935 cites W1997942208 @default.
• W1978370935 cites W2022656344 @default.
• W1978370935 cites W2027713583 @default.
• W1978370935 cites W2028668457 @default.
• W1978370935 cites W2029586372 @default.
• W1978370935 cites W2033151532 @default.
• W1978370935 cites W2034778680 @default.
• W1978370935 cites W2040674328 @default.
• W1978370935 cites W2045835520 @default.
• W1978370935 cites W2061539393 @default.
• W1978370935 cites W2072525595 @default.
• W1978370935 cites W2090096946 @default.
• W1978370935 cites W2092870550 @default.
• W1978370935 cites W2096659232 @default.
• W1978370935 cites W2101876919 @default.
• W1978370935 cites W2103465143 @default.
• W1978370935 cites W2104300284 @default.
• W1978370935 cites W2109224187 @default.
• W1978370935 cites W2110846909 @default.
• W1978370935 cites W2113796991 @default.
• W1978370935 cites W2115105291 @default.
• W1978370935 cites W2120869094 @default.
• W1978370935 cites W2121888318 @default.
• W1978370935 cites W2124163128 @default.
• W1978370935 cites W2130038381 @default.
• W1978370935 cites W2130528787 @default.
• W1978370935 cites W2133476676 @default.
• W1978370935 cites W2137353408 @default.
• W1978370935 cites W2140882931 @default.
• W1978370935 cites W2143055286 @default.
• W1978370935 cites W2144475254 @default.
• W1978370935 cites W2155963578 @default.
• W1978370935 cites W2157752701 @default.
• W1978370935 cites W2160606169 @default.
• W1978370935 cites W2164027460 @default.
• W1978370935 cites W2168421628 @default.
• W1978370935 cites W2169463741 @default.
• W1978370935 cites W2171777347 @default.
• W1978370935 cites W4231752535 @default.
• W1978370935 doi "https://doi.org/10.1158/1055-9965.epi-14-0815" @default.
• W1978370935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4294952" @default.
• W1978370935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25293881" @default.
• W1978370935 hasPublicationYear "2015" @default.
• W1978370935 type Work @default.
• W1978370935 sameAs 1978370935 @default.
• W1978370935 citedByCount "45" @default.
• W1978370935 countsByYear W19783709352015 @default.
• W1978370935 countsByYear W19783709352016 @default.
• W1978370935 countsByYear W19783709352017 @default.
• W1978370935 countsByYear W19783709352018 @default.
• W1978370935 countsByYear W19783709352019 @default.
• W1978370935 countsByYear W19783709352020 @default.
• W1978370935 countsByYear W19783709352021 @default.
• W1978370935 countsByYear W19783709352022 @default.
• W1978370935 countsByYear W19783709352023 @default.
• W1978370935 crossrefType "journal-article" @default.
• W1978370935 hasAuthorship W1978370935A5013179873 @default.
• W1978370935 hasAuthorship W1978370935A5016405051 @default.
• W1978370935 hasAuthorship W1978370935A5022126431 @default.
• W1978370935 hasAuthorship W1978370935A5037748128 @default.
• W1978370935 hasAuthorship W1978370935A5046710077 @default.
• W1978370935 hasAuthorship W1978370935A5053074659 @default.
• W1978370935 hasAuthorship W1978370935A5063065323 @default.
• W1978370935 hasAuthorship W1978370935A5063459619 @default.
• W1978370935 hasBestOaLocation W19783709351 @default.
• W1978370935 hasConcept C104317684 @default.
• W1978370935 hasConcept C126322002 @default.
• W1978370935 hasConcept C135763542 @default.
• W1978370935 hasConcept C139275648 @default.
• W1978370935 hasConcept C153209595 @default.
• W1978370935 hasConcept C202751555 @default.
• W1978370935 hasConcept C2776319443 @default.
• W1978370935 hasConcept C2779547902 @default.
• W1978370935 hasConcept C2779907587 @default.
• W1978370935 hasConcept C42407357 @default.
• W1978370935 hasConcept C54355233 @default.
• W1978370935 hasConcept C71924100 @default.

• next