FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978371146> ?p ?o ?g. }

• W1978371146 endingPage "1442" @default.
• W1978371146 startingPage "1430" @default.
• W1978371146 abstract "Tissue hypoxia/ischemia are major pathophysiological determinants. Conditions of decreased oxygen availability provoke accumulation and activation of hypoxia-inducible factor-1 (HIF-1). Recent reports demonstrate a crucial role of HIF-1 for inflammatory events. Regulation of hypoxic responses by the inflammatory mediators nitric oxide (NO) and reactive oxygen species (ROS) is believed to be of pathophysiolgical relevance. It is reported that hypoxic stabilization of HIF-1α can be antagonized by NO due to its ability to attenuate mitochondrial electron transport. Likely, the formation of ROS could contribute to this effect. As conflicting results emerged from several studies showing either decreased or increased ROS production during hypoxia, we used experiments mimicking hypoxic intracellular ROS changes by using the redox cycling agent 2,3-dimethoxy-1,4-naphthoquinone (DMNQ), which generates superoxide inside cells. Treatment of A549, HEK293, HepG2, and COS cells with DMNQ resulted in a concentration-dependent raise in ROS which correlated with HIF-1α accumulation. By using a HIF-1α–von Hippel-Lindau tumor suppressor protein binding assay, we show that ROS produced by DMNQ impaired prolyl hydroxylase activity. When HIF-1α is stabilized by NO, low concentrations of DMNQ (<1 μM) revealed no effect, intermediate concentrations of 1 to 40 μM DMNQ attenuated HIF-1α accumulation and higher concentrations of DMNQ promoted HIF-1α stability. Attenuation of NO-induced HIF-1α stability regulation by ROS was mediated by an active proteasomal degradation pathway. In conclusion, we propose that scavenging of NO by ROS and vice versa attenuate HIF-1α accumulation in a concentration-dependent manner. This is important to fully elucidate HIF-1α regulation under inflammatory conditions." @default.
• W1978371146 created "2016-06-24" @default.
• W1978371146 creator A5026207602 @default.
• W1978371146 creator A5055765928 @default.
• W1978371146 creator A5056936426 @default.
• W1978371146 date "2006-04-01" @default.
• W1978371146 modified "2023-10-16" @default.
• W1978371146 title "Reactive oxygen species attenuate nitric-oxide-mediated hypoxia-inducible factor-1α stabilization" @default.
• W1978371146 cites W1547863599 @default.
• W1978371146 cites W1891283175 @default.
• W1978371146 cites W1963545628 @default.
• W1978371146 cites W1964037605 @default.
• W1978371146 cites W1967729440 @default.
• W1978371146 cites W1972126340 @default.
• W1978371146 cites W1972887746 @default.
• W1978371146 cites W1973517763 @default.
• W1978371146 cites W1991308916 @default.
• W1978371146 cites W1991843895 @default.
• W1978371146 cites W1994087300 @default.
• W1978371146 cites W1998905001 @default.
• W1978371146 cites W2002575458 @default.
• W1978371146 cites W2004118426 @default.
• W1978371146 cites W2005868568 @default.
• W1978371146 cites W2020247531 @default.
• W1978371146 cites W2025275904 @default.
• W1978371146 cites W2026085787 @default.
• W1978371146 cites W2030319693 @default.
• W1978371146 cites W2033453582 @default.
• W1978371146 cites W2034453401 @default.
• W1978371146 cites W2037879643 @default.
• W1978371146 cites W2040031153 @default.
• W1978371146 cites W2042196624 @default.
• W1978371146 cites W2044301758 @default.
• W1978371146 cites W2046018661 @default.
• W1978371146 cites W2046905314 @default.
• W1978371146 cites W2047785585 @default.
• W1978371146 cites W2048443173 @default.
• W1978371146 cites W2049089334 @default.
• W1978371146 cites W2051123785 @default.
• W1978371146 cites W2051908396 @default.
• W1978371146 cites W2055902411 @default.
• W1978371146 cites W2061352347 @default.
• W1978371146 cites W2070101900 @default.
• W1978371146 cites W2072634616 @default.
• W1978371146 cites W2073132923 @default.
• W1978371146 cites W2075610315 @default.
• W1978371146 cites W2080374319 @default.
• W1978371146 cites W2089692551 @default.
• W1978371146 cites W2091917736 @default.
• W1978371146 cites W2094267083 @default.
• W1978371146 cites W2095062583 @default.
• W1978371146 cites W2103154710 @default.
• W1978371146 cites W2117236885 @default.
• W1978371146 cites W2120090919 @default.
• W1978371146 cites W2133258970 @default.
• W1978371146 cites W2137179853 @default.
• W1978371146 cites W2144625075 @default.
• W1978371146 cites W2147993424 @default.
• W1978371146 cites W2149472502 @default.
• W1978371146 cites W2150916538 @default.
• W1978371146 cites W2154084724 @default.
• W1978371146 cites W2156277739 @default.
• W1978371146 cites W2160866228 @default.
• W1978371146 cites W2161877652 @default.
• W1978371146 cites W2490164259 @default.
• W1978371146 cites W4254763216 @default.
• W1978371146 doi "https://doi.org/10.1016/j.freeradbiomed.2005.12.012" @default.
• W1978371146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16631533" @default.
• W1978371146 hasPublicationYear "2006" @default.
• W1978371146 type Work @default.
• W1978371146 sameAs 1978371146 @default.
• W1978371146 citedByCount "62" @default.
• W1978371146 countsByYear W19783711462012 @default.
• W1978371146 countsByYear W19783711462013 @default.
• W1978371146 countsByYear W19783711462014 @default.
• W1978371146 countsByYear W19783711462015 @default.
• W1978371146 countsByYear W19783711462016 @default.
• W1978371146 countsByYear W19783711462017 @default.
• W1978371146 countsByYear W19783711462018 @default.
• W1978371146 countsByYear W19783711462019 @default.
• W1978371146 countsByYear W19783711462020 @default.
• W1978371146 countsByYear W19783711462021 @default.
• W1978371146 countsByYear W19783711462022 @default.
• W1978371146 countsByYear W19783711462023 @default.
• W1978371146 crossrefType "journal-article" @default.
• W1978371146 hasAuthorship W1978371146A5026207602 @default.
• W1978371146 hasAuthorship W1978371146A5055765928 @default.
• W1978371146 hasAuthorship W1978371146A5056936426 @default.
• W1978371146 hasConcept C104317684 @default.
• W1978371146 hasConcept C12554922 @default.
• W1978371146 hasConcept C160450060 @default.
• W1978371146 hasConcept C178790620 @default.
• W1978371146 hasConcept C181199279 @default.
• W1978371146 hasConcept C185592680 @default.
• W1978371146 hasConcept C2778175917 @default.
• W1978371146 hasConcept C2780795997 @default.
• W1978371146 hasConcept C48349386 @default.
• W1978371146 hasConcept C519581460 @default.

• next