FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978371504> ?p ?o ?g. }

• W1978371504 endingPage "15777" @default.
• W1978371504 startingPage "15772" @default.
• W1978371504 abstract "This study identifies and characterizes retinal stem cells (RSCs) in early postnatal to seventh-decade human eyes. Different subregions of human eyes were dissociated and cultured by using a clonal sphere-forming assay. The stem cells were derived only from the pars plicata and pars plana of the retinal ciliary margin, at a frequency of approximately 1:500. To test for long-term self-renewal, both the sphere assay and monolayer passaging were used. By using the single sphere passaging assay, primary spheres were dissociated and replated, and individual spheres demonstrated 100% self-renewal, with single spheres giving rise to one or more new spheres in each subsequent passage. The clonal retinal spheres were plated under differentiation conditions to assay the differentiation potential of their progeny. The spheres were produced all of the different retinal cell types, demonstrating multipotentiality. Therefore, the human eye contains a small population of cells (approximately equal to 10,000 cells per eye) that have retinal stem-cell characteristics (proliferation, self-renewal, and multipotentiality). To test the in vivo potential of the stem cells and their progeny, we transplanted dissociated human retinal sphere cells, containing both stem cells and progenitors, into the eyes of postnatal day 1 NOD/SCID mice and embryonic chick eyes. The progeny of the RSCs were able to survive, migrate, integrate, and differentiate into the neural retina, especially as photoreceptors. Their facile isolation, integration, and differentiation suggest that human RSCs eventually may be valuable in treating human retinal diseases." @default.
• W1978371504 created "2016-06-24" @default.
• W1978371504 creator A5019335002 @default.
• W1978371504 creator A5025707835 @default.
• W1978371504 creator A5040983764 @default.
• W1978371504 creator A5045665412 @default.
• W1978371504 creator A5068559099 @default.
• W1978371504 creator A5079126457 @default.
• W1978371504 creator A5080762743 @default.
• W1978371504 creator A5091583556 @default.
• W1978371504 date "2004-10-25" @default.
• W1978371504 modified "2023-10-11" @default.
• W1978371504 title "Facile isolation and the characterization of human retinal stem cells" @default.
• W1978371504 cites W1835972708 @default.
• W1978371504 cites W1871719070 @default.
• W1978371504 cites W1989696297 @default.
• W1978371504 cites W1993693950 @default.
• W1978371504 cites W2003321684 @default.
• W1978371504 cites W2003994112 @default.
• W1978371504 cites W2014512545 @default.
• W1978371504 cites W2016552437 @default.
• W1978371504 cites W2024573693 @default.
• W1978371504 cites W2024667339 @default.
• W1978371504 cites W2026700123 @default.
• W1978371504 cites W2032594449 @default.
• W1978371504 cites W2046450144 @default.
• W1978371504 cites W2060572966 @default.
• W1978371504 cites W2063498603 @default.
• W1978371504 cites W2067198472 @default.
• W1978371504 cites W2092010535 @default.
• W1978371504 cites W2109801441 @default.
• W1978371504 cites W2114268866 @default.
• W1978371504 cites W2119727278 @default.
• W1978371504 cites W2127829230 @default.
• W1978371504 cites W2170960097 @default.
• W1978371504 doi "https://doi.org/10.1073/pnas.0401596101" @default.
• W1978371504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/524825" @default.
• W1978371504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15505221" @default.
• W1978371504 hasPublicationYear "2004" @default.
• W1978371504 type Work @default.
• W1978371504 sameAs 1978371504 @default.
• W1978371504 citedByCount "382" @default.
• W1978371504 countsByYear W19783715042012 @default.
• W1978371504 countsByYear W19783715042013 @default.
• W1978371504 countsByYear W19783715042014 @default.
• W1978371504 countsByYear W19783715042015 @default.
• W1978371504 countsByYear W19783715042016 @default.
• W1978371504 countsByYear W19783715042017 @default.
• W1978371504 countsByYear W19783715042018 @default.
• W1978371504 countsByYear W19783715042019 @default.
• W1978371504 countsByYear W19783715042020 @default.
• W1978371504 countsByYear W19783715042021 @default.
• W1978371504 countsByYear W19783715042022 @default.
• W1978371504 countsByYear W19783715042023 @default.
• W1978371504 crossrefType "journal-article" @default.
• W1978371504 hasAuthorship W1978371504A5019335002 @default.
• W1978371504 hasAuthorship W1978371504A5025707835 @default.
• W1978371504 hasAuthorship W1978371504A5040983764 @default.
• W1978371504 hasAuthorship W1978371504A5045665412 @default.
• W1978371504 hasAuthorship W1978371504A5068559099 @default.
• W1978371504 hasAuthorship W1978371504A5079126457 @default.
• W1978371504 hasAuthorship W1978371504A5080762743 @default.
• W1978371504 hasAuthorship W1978371504A5091583556 @default.
• W1978371504 hasBestOaLocation W19783715042 @default.
• W1978371504 hasConcept C104317684 @default.
• W1978371504 hasConcept C145103041 @default.
• W1978371504 hasConcept C169760540 @default.
• W1978371504 hasConcept C201750760 @default.
• W1978371504 hasConcept C203014093 @default.
• W1978371504 hasConcept C2777093970 @default.
• W1978371504 hasConcept C2780827179 @default.
• W1978371504 hasConcept C28328180 @default.
• W1978371504 hasConcept C54355233 @default.
• W1978371504 hasConcept C55493867 @default.
• W1978371504 hasConcept C86803240 @default.
• W1978371504 hasConcept C95444343 @default.
• W1978371504 hasConceptScore W1978371504C104317684 @default.
• W1978371504 hasConceptScore W1978371504C145103041 @default.
• W1978371504 hasConceptScore W1978371504C169760540 @default.
• W1978371504 hasConceptScore W1978371504C201750760 @default.
• W1978371504 hasConceptScore W1978371504C203014093 @default.
• W1978371504 hasConceptScore W1978371504C2777093970 @default.
• W1978371504 hasConceptScore W1978371504C2780827179 @default.
• W1978371504 hasConceptScore W1978371504C28328180 @default.
• W1978371504 hasConceptScore W1978371504C54355233 @default.
• W1978371504 hasConceptScore W1978371504C55493867 @default.
• W1978371504 hasConceptScore W1978371504C86803240 @default.
• W1978371504 hasConceptScore W1978371504C95444343 @default.
• W1978371504 hasIssue "44" @default.
• W1978371504 hasLocation W19783715041 @default.
• W1978371504 hasLocation W19783715042 @default.
• W1978371504 hasLocation W19783715043 @default.
• W1978371504 hasLocation W19783715044 @default.
• W1978371504 hasOpenAccess W1978371504 @default.
• W1978371504 hasPrimaryLocation W19783715041 @default.
• W1978371504 hasRelatedWork W1948903846 @default.
• W1978371504 hasRelatedWork W1977334515 @default.
• W1978371504 hasRelatedWork W2027168247 @default.

• next