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- W1978371955 abstract "The testes of a variety of mammalian species have been reported to be sensitive to a subcutaneous or intraperitoneal injection of cadmium chloride at a dosage level of 0m=.02to 0m=.04mm-CdCl2/kg body weight (rat: Pal=r%vl=i'zek,1957, 1960; Mason, Brown, Young & Nesbitt, 1964; Gunn, Gould & Anderson, 1961; Kar & Das, 1960; mouse: Meek, 1959; Chiquoine, 1964; rabbit: Pal=r%vl=i'zek, 1960; Cameron & Foster, 1963; hamster: Pal=r%vl=i'zek,1960; guinea-pig: Pal=r%vl=i'zek 1960) and the necrosis of the testis which follows such an injection has been described by these same authors. The rabbit, however, has been reported to be sensitive by Pal=r%vl=i'zek(1960) and by Cameron & Foster (1963) but to be insensitive by Smith, Smith & McCall (1960). Kar & Das (1962) found no testicular necrosis 30 days after a single subcutaneous injection of 10 mg CdCl2/ kg body weight but did observe the typical picture of cadmium necrosis 5 days after an intratesticular injection of 200 g=m/kgCdCl2. These authors suggest that, following a subcutaneous injection of cadmium in their laboratory rabbits, the necessary critical concentration of cadmium within the testis was not attained, but that this concentration can be attained after an intratesticular injection. These observations suggest that there are differences in cadmium sensitivity between strains of rabbits. Chance observations in our own laboratory suggested differences in susceptibility to cadmium also between strains of mice. Eight strains ofmice were therefore tested for their sensitivity to subcutaneous injections of 0m=.02to 0m=.04mm-CdCl2/kg body weight; not less than five mice of a given strain were tested in every case. Animals were injected with 0m=.075" @default.
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- W1978371955 date "1965-12-01" @default.
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- W1978371955 title "SENSITIVITY OF MAMMALS TO CADMIUM NECROSIS OF THE TESTIS" @default.
- W1978371955 doi "https://doi.org/10.1530/jrf.0.0100455" @default.
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