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- W1978373944 abstract "Recombinant human interleukin-11 (rhIL-11) has been shown to enhance recovery from thrombocytopenia and mucosal injury after cancer chemotherapy. Since RNA for the receptor and signal transducer for IL-11 is detected in many cell types including some cancer cells, it was theoretically possible that rhlL-11 could affect the growth of tumor cells. This study was intended to determine whether rhlL-11 stimulates the proliferation of human tumor colony-forming units (TCFUs) taken directly from patients. Tumor cells were cultured in soft agar and continuously exposed to three concentrations of rhlL-11 (1.0, 10.0 and 100.0 U/ml) for 14 days in the capillary cloning system. Growth stimulation was noted in two of 66 (3%) of evaluable specimens, including one of 14 evaluable non-small cell lung cancer and one of five evaluable colon cancer specimens. In these two specimens, there was no increased stimulation of TCFUs with escaiating concentrations of rhlL-11. Interestingly, the highest concentration of rhlL-11 tested Inhibited the growth of 16 specimens (24.2%; 95% confidence Interval 13.9–34.5%). Growth inhibition demonstrated a concentration-response relationship (p< 0.001). These results suggest that rhlL-11 appears unlikely to stimulate the growth of the most common solid tumors." @default.
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- W1978373944 date "1999-01-01" @default.
- W1978373944 modified "2023-09-26" @default.
- W1978373944 title "Recombinant human interleukin-11 is unlikely to stimulate the growth of the most common solid tumors" @default.
- W1978373944 doi "https://doi.org/10.1097/00001813-199901000-00012" @default.
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