FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978375298> ?p ?o ?g. }

• W1978375298 endingPage "248" @default.
• W1978375298 startingPage "242" @default.
• W1978375298 abstract "Wnt5a has been implicated in the activation of macrophages. However, the profile and mechanism of downstream regulation has not been characterized. In this study, we have investigated the regulation of Wnt5a-induced activation in monocytic THP-1 cells. Wnt5a activated THP-1 cells, enhancing adhesion to endothelial cells. Hypoxia induced the production of Wnt5a, suggesting a role in the hypoxia-induced activation of macrophages. Wnt5a induced the expression of various pro-inflammatory cytokines and inflammatory mediators, particularly IL8 and CXCL2, suggesting a major role in the secretion of CXC chemokines by macrophages. Wnt5a induced JNK phosphorylation and NF-κB activation via β-catenin-independent signaling. Interestingly, SP600125, a specific inhibitor of JNK, inhibited Wnt5a-induced activation of NF-κB, supporting JNK-dependent NF-κB activation. Our data suggest that Wnt5a activates monocytic cells via JNK and NF-κB activation." @default.
• W1978375298 created "2016-06-24" @default.
• W1978375298 creator A5008245269 @default.
• W1978375298 creator A5057244753 @default.
• W1978375298 creator A5059410924 @default.
• W1978375298 creator A5072442727 @default.
• W1978375298 creator A5074383894 @default.
• W1978375298 date "2012-10-01" @default.
• W1978375298 modified "2023-10-12" @default.
• W1978375298 title "Wnt5a activates THP-1 monocytic cells via a β-catenin-independent pathway involving JNK and NF-κB activation" @default.
• W1978375298 cites W1826797943 @default.
• W1978375298 cites W1970548725 @default.
• W1978375298 cites W1982148505 @default.
• W1978375298 cites W1986158200 @default.
• W1978375298 cites W2006595571 @default.
• W1978375298 cites W2009684443 @default.
• W1978375298 cites W2015974087 @default.
• W1978375298 cites W2018204780 @default.
• W1978375298 cites W2026927520 @default.
• W1978375298 cites W2033586457 @default.
• W1978375298 cites W2052446965 @default.
• W1978375298 cites W2054472394 @default.
• W1978375298 cites W2067056588 @default.
• W1978375298 cites W2068981042 @default.
• W1978375298 cites W2087959682 @default.
• W1978375298 cites W2100701799 @default.
• W1978375298 cites W2114318388 @default.
• W1978375298 cites W2114963537 @default.
• W1978375298 cites W2117695549 @default.
• W1978375298 cites W2122044177 @default.
• W1978375298 cites W2124701846 @default.
• W1978375298 cites W2125050685 @default.
• W1978375298 cites W2130873698 @default.
• W1978375298 cites W2158969445 @default.
• W1978375298 cites W2159724914 @default.
• W1978375298 cites W4243541841 @default.
• W1978375298 doi "https://doi.org/10.1016/j.cyto.2012.06.013" @default.
• W1978375298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22763043" @default.
• W1978375298 hasPublicationYear "2012" @default.
• W1978375298 type Work @default.
• W1978375298 sameAs 1978375298 @default.
• W1978375298 citedByCount "28" @default.
• W1978375298 countsByYear W19783752982013 @default.
• W1978375298 countsByYear W19783752982014 @default.
• W1978375298 countsByYear W19783752982015 @default.
• W1978375298 countsByYear W19783752982016 @default.
• W1978375298 countsByYear W19783752982017 @default.
• W1978375298 countsByYear W19783752982018 @default.
• W1978375298 countsByYear W19783752982019 @default.
• W1978375298 countsByYear W19783752982020 @default.
• W1978375298 countsByYear W19783752982021 @default.
• W1978375298 countsByYear W19783752982022 @default.
• W1978375298 countsByYear W19783752982023 @default.
• W1978375298 crossrefType "journal-article" @default.
• W1978375298 hasAuthorship W1978375298A5008245269 @default.
• W1978375298 hasAuthorship W1978375298A5057244753 @default.
• W1978375298 hasAuthorship W1978375298A5059410924 @default.
• W1978375298 hasAuthorship W1978375298A5072442727 @default.
• W1978375298 hasAuthorship W1978375298A5074383894 @default.
• W1978375298 hasConcept C101666144 @default.
• W1978375298 hasConcept C11960822 @default.
• W1978375298 hasConcept C12823836 @default.
• W1978375298 hasConcept C13373296 @default.
• W1978375298 hasConcept C137620995 @default.
• W1978375298 hasConcept C164027704 @default.
• W1978375298 hasConcept C170493617 @default.
• W1978375298 hasConcept C179661763 @default.
• W1978375298 hasConcept C185592680 @default.
• W1978375298 hasConcept C203014093 @default.
• W1978375298 hasConcept C204258353 @default.
• W1978375298 hasConcept C2776914184 @default.
• W1978375298 hasConcept C2777730290 @default.
• W1978375298 hasConcept C2780176071 @default.
• W1978375298 hasConcept C54166955 @default.
• W1978375298 hasConcept C54355233 @default.
• W1978375298 hasConcept C55493867 @default.
• W1978375298 hasConcept C62478195 @default.
• W1978375298 hasConcept C68324877 @default.
• W1978375298 hasConcept C81885089 @default.
• W1978375298 hasConcept C86803240 @default.
• W1978375298 hasConcept C95444343 @default.
• W1978375298 hasConceptScore W1978375298C101666144 @default.
• W1978375298 hasConceptScore W1978375298C11960822 @default.
• W1978375298 hasConceptScore W1978375298C12823836 @default.
• W1978375298 hasConceptScore W1978375298C13373296 @default.
• W1978375298 hasConceptScore W1978375298C137620995 @default.
• W1978375298 hasConceptScore W1978375298C164027704 @default.
• W1978375298 hasConceptScore W1978375298C170493617 @default.
• W1978375298 hasConceptScore W1978375298C179661763 @default.
• W1978375298 hasConceptScore W1978375298C185592680 @default.
• W1978375298 hasConceptScore W1978375298C203014093 @default.
• W1978375298 hasConceptScore W1978375298C204258353 @default.
• W1978375298 hasConceptScore W1978375298C2776914184 @default.
• W1978375298 hasConceptScore W1978375298C2777730290 @default.
• W1978375298 hasConceptScore W1978375298C2780176071 @default.
• W1978375298 hasConceptScore W1978375298C54166955 @default.
• W1978375298 hasConceptScore W1978375298C54355233 @default.
• W1978375298 hasConceptScore W1978375298C55493867 @default.

• next