FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978375825> ?p ?o ?g. }

• W1978375825 endingPage "e115306" @default.
• W1978375825 startingPage "e115306" @default.
• W1978375825 abstract "Platelets are anuclear cell fragments derived from bone marrow megakaryocytes that safeguard vascular integrity by forming thrombi at sites of vascular injury. Although the early events of thrombus formation--platelet adhesion and aggregation--have been intensively studied, less is known about the mechanisms and receptors that stabilize platelet-platelet interactions once a thrombus has formed. One receptor that has been implicated in this process is the signaling lymphocyte activation molecule (SLAM) family member CD84, which can undergo homophilic interactions and becomes phosphorylated upon platelet aggregation.The role of CD84 in platelet physiology and thrombus formation was investigated in CD84-deficient mice.We generated CD84-deficient mice and analyzed their platelets in vitro and in vivo. Cd84(-/-) platelets exhibited normal activation and aggregation responses to classical platelet agonists. Furthermore, CD84 deficiency did not affect integrin-mediated clot retraction and spreading of activated platelets on fibrinogen. Notably, also the formation of stable three-dimensional thrombi on collagen-coated surfaces under flow ex vivo was unaltered in the blood of Cd84(-/-) mice. In vivo, Cd84(-/-) mice exhibited unaltered hemostatic function and arterial thrombus formation.These results show that CD84 is dispensable for thrombus formation and stabilization, indicating that its deficiency may be functionally compensated by other receptors or that it may be important for platelet functions different from platelet-platelet interactions." @default.
• W1978375825 created "2016-06-24" @default.
• W1978375825 creator A5008888080 @default.
• W1978375825 creator A5012265738 @default.
• W1978375825 creator A5013543384 @default.
• W1978375825 creator A5019067219 @default.
• W1978375825 creator A5060697463 @default.
• W1978375825 creator A5079584981 @default.
• W1978375825 date "2014-12-31" @default.
• W1978375825 modified "2023-09-26" @default.
• W1978375825 title "Mice Lacking the SLAM Family Member CD84 Display Unaltered Platelet Function in Hemostasis and Thrombosis" @default.
• W1978375825 cites W1481634568 @default.
• W1978375825 cites W1493547476 @default.
• W1978375825 cites W1522096076 @default.
• W1978375825 cites W1549514523 @default.
• W1978375825 cites W1601066507 @default.
• W1978375825 cites W1924175076 @default.
• W1978375825 cites W1965740748 @default.
• W1978375825 cites W1966226088 @default.
• W1978375825 cites W1966697925 @default.
• W1978375825 cites W1980408283 @default.
• W1978375825 cites W1990451715 @default.
• W1978375825 cites W2029976550 @default.
• W1978375825 cites W2032242135 @default.
• W1978375825 cites W2038469874 @default.
• W1978375825 cites W2046752806 @default.
• W1978375825 cites W2047800110 @default.
• W1978375825 cites W2054540030 @default.
• W1978375825 cites W2062045566 @default.
• W1978375825 cites W2074506841 @default.
• W1978375825 cites W2087411946 @default.
• W1978375825 cites W2091401363 @default.
• W1978375825 cites W2093529736 @default.
• W1978375825 cites W2102378371 @default.
• W1978375825 cites W2108167539 @default.
• W1978375825 cites W2117175029 @default.
• W1978375825 cites W2122510983 @default.
• W1978375825 cites W2146182770 @default.
• W1978375825 cites W2146494375 @default.
• W1978375825 cites W2284815995 @default.
• W1978375825 cites W252852947 @default.
• W1978375825 cites W4210564819 @default.
• W1978375825 cites W4239907137 @default.
• W1978375825 cites W4249606224 @default.
• W1978375825 cites W46649957 @default.
• W1978375825 doi "https://doi.org/10.1371/journal.pone.0115306" @default.
• W1978375825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4281120" @default.
• W1978375825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25551754" @default.
• W1978375825 hasPublicationYear "2014" @default.
• W1978375825 type Work @default.
• W1978375825 sameAs 1978375825 @default.
• W1978375825 citedByCount "14" @default.
• W1978375825 countsByYear W19783758252015 @default.
• W1978375825 countsByYear W19783758252016 @default.
• W1978375825 countsByYear W19783758252017 @default.
• W1978375825 countsByYear W19783758252018 @default.
• W1978375825 countsByYear W19783758252019 @default.
• W1978375825 countsByYear W19783758252020 @default.
• W1978375825 countsByYear W19783758252022 @default.
• W1978375825 crossrefType "journal-article" @default.
• W1978375825 hasAuthorship W1978375825A5008888080 @default.
• W1978375825 hasAuthorship W1978375825A5012265738 @default.
• W1978375825 hasAuthorship W1978375825A5013543384 @default.
• W1978375825 hasAuthorship W1978375825A5019067219 @default.
• W1978375825 hasAuthorship W1978375825A5060697463 @default.
• W1978375825 hasAuthorship W1978375825A5079584981 @default.
• W1978375825 hasBestOaLocation W19783758251 @default.
• W1978375825 hasConcept C126322002 @default.
• W1978375825 hasConcept C150903083 @default.
• W1978375825 hasConcept C185592680 @default.
• W1978375825 hasConcept C203014093 @default.
• W1978375825 hasConcept C207001950 @default.
• W1978375825 hasConcept C26291073 @default.
• W1978375825 hasConcept C2777292125 @default.
• W1978375825 hasConcept C2778589496 @default.
• W1978375825 hasConcept C2778863912 @default.
• W1978375825 hasConcept C2779036427 @default.
• W1978375825 hasConcept C2780009322 @default.
• W1978375825 hasConcept C2780573682 @default.
• W1978375825 hasConcept C2781362458 @default.
• W1978375825 hasConcept C2993802102 @default.
• W1978375825 hasConcept C3018697912 @default.
• W1978375825 hasConcept C55493867 @default.
• W1978375825 hasConcept C71924100 @default.
• W1978375825 hasConcept C86803240 @default.
• W1978375825 hasConcept C89560881 @default.
• W1978375825 hasConcept C95444343 @default.
• W1978375825 hasConceptScore W1978375825C126322002 @default.
• W1978375825 hasConceptScore W1978375825C150903083 @default.
• W1978375825 hasConceptScore W1978375825C185592680 @default.
• W1978375825 hasConceptScore W1978375825C203014093 @default.
• W1978375825 hasConceptScore W1978375825C207001950 @default.
• W1978375825 hasConceptScore W1978375825C26291073 @default.
• W1978375825 hasConceptScore W1978375825C2777292125 @default.
• W1978375825 hasConceptScore W1978375825C2778589496 @default.
• W1978375825 hasConceptScore W1978375825C2778863912 @default.
• W1978375825 hasConceptScore W1978375825C2779036427 @default.
• W1978375825 hasConceptScore W1978375825C2780009322 @default.

• next