FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978377990> ?p ?o ?g. }

• W1978377990 endingPage "929" @default.
• W1978377990 startingPage "923" @default.
• W1978377990 abstract "<h2>Abstract</h2> Autosomal dominant polycystic kidney disease (ADPKD) is a serious cause of renal failure. In many renal-disease models, surgical renal mass reduction accelerates disease progression. We explored whether surgical renal mass reduction and the method of renal mass reduction accelerate the course of ADPKD. Studies were conducted in male heterozygous cystic Han:SPRD rats and unaffected littermate controls. Control and cystic rats were subjected to 50% renal mass reduction by uninephrectomy, 50% renal mass reduction by infarction of half of each kidney, or sham operation. Most groups were followed up to the age of 20 weeks, with serial measurements of blood pressure and proteinuria. At 20 weeks, glomerular filtration rate (GFR) and renal plasma flow (RPF) rate were measured. Similar studies to 12 weeks of age were performed in additional groups of control and cystic rats with either sham operation or 50% renal infarction. In noncystic rats, uninephrectomy led to minimal effects on blood pressure and proteinuria and to substantial compensatory renal hypertrophy, hyperfiltration, and hyperperfusion. Similar renal mass reduction by segmental infarction led to greater values for blood pressure and proteinuria and significant compensatory hyperfiltration. In contrast, the cystic rats showed a significant reduction in baseline renal blood flow, more profound increases in blood pressure and proteinuria, and no compensatory increases in GFR and RPF after reduction of renal mass. These studies suggest that the ability of cystic kidneys to respond to acquired loss of nephrons is impaired and that these kidneys are at greater risk when additional renal injury is superimposed." @default.
• W1978377990 created "2016-06-24" @default.
• W1978377990 creator A5008041834 @default.
• W1978377990 creator A5024812806 @default.
• W1978377990 creator A5049739456 @default.
• W1978377990 creator A5052101148 @default.
• W1978377990 creator A5053221951 @default.
• W1978377990 date "2000-05-01" @default.
• W1978377990 modified "2023-10-16" @default.
• W1978377990 title "Impaired adaptation to renal mass reduction in the polycystic rat" @default.
• W1978377990 cites W1924478590 @default.
• W1978377990 cites W1927993343 @default.
• W1978377990 cites W1981202916 @default.
• W1978377990 cites W2004432084 @default.
• W1978377990 cites W2006152064 @default.
• W1978377990 cites W2009877207 @default.
• W1978377990 cites W2012159432 @default.
• W1978377990 cites W2013073525 @default.
• W1978377990 cites W2023247388 @default.
• W1978377990 cites W2031534703 @default.
• W1978377990 cites W2032669447 @default.
• W1978377990 cites W2034944255 @default.
• W1978377990 cites W2055759982 @default.
• W1978377990 cites W2061166866 @default.
• W1978377990 cites W2083917318 @default.
• W1978377990 cites W2086071801 @default.
• W1978377990 cites W2093833100 @default.
• W1978377990 cites W2095475063 @default.
• W1978377990 cites W2128219017 @default.
• W1978377990 cites W2129794215 @default.
• W1978377990 cites W2132018948 @default.
• W1978377990 cites W2199919057 @default.
• W1978377990 cites W2243393341 @default.
• W1978377990 cites W2264139579 @default.
• W1978377990 cites W2403760519 @default.
• W1978377990 cites W2414767483 @default.
• W1978377990 cites W2439898143 @default.
• W1978377990 cites W2441270763 @default.
• W1978377990 doi "https://doi.org/10.1016/s0272-6386(00)70264-2" @default.
• W1978377990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10793028" @default.
• W1978377990 hasPublicationYear "2000" @default.
• W1978377990 type Work @default.
• W1978377990 sameAs 1978377990 @default.
• W1978377990 citedByCount "4" @default.
• W1978377990 crossrefType "journal-article" @default.
• W1978377990 hasAuthorship W1978377990A5008041834 @default.
• W1978377990 hasAuthorship W1978377990A5024812806 @default.
• W1978377990 hasAuthorship W1978377990A5049739456 @default.
• W1978377990 hasAuthorship W1978377990A5052101148 @default.
• W1978377990 hasAuthorship W1978377990A5053221951 @default.
• W1978377990 hasConcept C126322002 @default.
• W1978377990 hasConcept C126894567 @default.
• W1978377990 hasConcept C134018914 @default.
• W1978377990 hasConcept C142225936 @default.
• W1978377990 hasConcept C159641895 @default.
• W1978377990 hasConcept C164705383 @default.
• W1978377990 hasConcept C177669144 @default.
• W1978377990 hasConcept C21652263 @default.
• W1978377990 hasConcept C2776266639 @default.
• W1978377990 hasConcept C2778653478 @default.
• W1978377990 hasConcept C2779561371 @default.
• W1978377990 hasConcept C2780091579 @default.
• W1978377990 hasConcept C2780145431 @default.
• W1978377990 hasConcept C71924100 @default.
• W1978377990 hasConcept C84393581 @default.
• W1978377990 hasConceptScore W1978377990C126322002 @default.
• W1978377990 hasConceptScore W1978377990C126894567 @default.
• W1978377990 hasConceptScore W1978377990C134018914 @default.
• W1978377990 hasConceptScore W1978377990C142225936 @default.
• W1978377990 hasConceptScore W1978377990C159641895 @default.
• W1978377990 hasConceptScore W1978377990C164705383 @default.
• W1978377990 hasConceptScore W1978377990C177669144 @default.
• W1978377990 hasConceptScore W1978377990C21652263 @default.
• W1978377990 hasConceptScore W1978377990C2776266639 @default.
• W1978377990 hasConceptScore W1978377990C2778653478 @default.
• W1978377990 hasConceptScore W1978377990C2779561371 @default.
• W1978377990 hasConceptScore W1978377990C2780091579 @default.
• W1978377990 hasConceptScore W1978377990C2780145431 @default.
• W1978377990 hasConceptScore W1978377990C71924100 @default.
• W1978377990 hasConceptScore W1978377990C84393581 @default.
• W1978377990 hasIssue "5" @default.
• W1978377990 hasLocation W19783779901 @default.
• W1978377990 hasLocation W19783779902 @default.
• W1978377990 hasOpenAccess W1978377990 @default.
• W1978377990 hasPrimaryLocation W19783779901 @default.
• W1978377990 hasRelatedWork W1783286868 @default.
• W1978377990 hasRelatedWork W1977762863 @default.
• W1978377990 hasRelatedWork W2003972033 @default.
• W1978377990 hasRelatedWork W2024078912 @default.
• W1978377990 hasRelatedWork W2120532078 @default.
• W1978377990 hasRelatedWork W2171325854 @default.
• W1978377990 hasRelatedWork W2175871704 @default.
• W1978377990 hasRelatedWork W2413530128 @default.
• W1978377990 hasRelatedWork W2418654739 @default.
• W1978377990 hasRelatedWork W2787754251 @default.
• W1978377990 hasVolume "35" @default.
• W1978377990 isParatext "false" @default.
• W1978377990 isRetracted "false" @default.

• next