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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978384022> ?p ?o ?g. }

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• W1978384022 abstract "The p38 alpha mitogen-activated protein kinase has been implicated in the cellular response to genotoxic agents. Here we show that another p38 family member is also activated in response to cisplatin exposure in human melanoma cells. We identified this isoform as p38gamma based on its recognition by specific antibodies and because, in contrast to p38alpha, its activity was not affected by SB203580. We also found that etoposide caused a much more discrete phosphorylation of both p38alpha and p38gamma than either cisplatin or UV treatment. These results indicate that genotoxic stresses activate several p38 isoforms whose implication in the cellular response might depend on the type of DNA damage." @default.
• W1978384022 created "2016-06-24" @default.
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• W1978384022 date "2000-11-01" @default.
• W1978384022 modified "2023-10-17" @default.
• W1978384022 title "Cisplatin and UV Radiation Induce Activation of the Stress-Activated Protein Kinase p38γ in Human Melanoma Cells" @default.
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• W1978384022 doi "https://doi.org/10.1006/bbrc.2000.3877" @default.
• W1978384022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11095975" @default.
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