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• W1978390594 abstract "In sub-Saharan Africa, Plasmodium falciparum and hepatitis A (HAV) infections are common, especially in children. Co-infections with these two pathogens may therefore occur, but it is unknown if temporal clustering exists.We studied the pattern of co-infection of P. falciparum malaria and acute HAV in Kenyan children under the age of 5 years in a cohort of children presenting with uncomplicated P. falciparum malaria. HAV status was determined during a 3-month follow-up period.Among 222 cases of uncomplicated malaria, 10 patients were anti-HAV IgM positive. The incidence of HAV infections during P. falciparum malaria was 1.7 (95% CI 0.81-3.1) infections/person-year while the cumulative incidence of HAV over the 3-month follow-up period was 0.27 (95% CI 0.14-0.50) infections/person-year. Children with or without HAV co-infections had similar mean P. falciparum asexual parasite densities at presentation (31,000/µL vs. 34,000/µL, respectively), largely exceeding the pyrogenic threshold of 2,500 parasites/µL in this population and minimizing risk of over-diagnosis of malaria as an explanation.The observed temporal association between acute HAV and P. falciparum malaria suggests that co-infections of these two hepatotrophic human pathogens may result from changes in host susceptibility. Testing this hypothesis will require larger prospective studies." @default.
• W1978390594 created "2016-06-24" @default.
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• W1978390594 date "2011-07-06" @default.
• W1978390594 modified "2023-09-26" @default.
• W1978390594 title "Temporal Association of Acute Hepatitis A and Plasmodium falciparum Malaria in Children" @default.
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• W1978390594 doi "https://doi.org/10.1371/journal.pone.0021013" @default.
• W1978390594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3130729" @default.
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