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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978390640> ?p ?o ?g. }

• W1978390640 endingPage "510" @default.
• W1978390640 startingPage "501" @default.
• W1978390640 abstract "Alterations in two highly conserved N-linked glycosylation sites within the gp120 envelope glycoprotein of human immunodeficiency virus type I (HIV-1) implicated in the phenotype of a noncytopathic HIV-1 variant were introduced independently and in combination into a cytopathic, infectious HIV-1 clone by site-specific mutagenesis. Neither mutation affected the synthesis of HIV-1 envelope glycoproteins. However, one of the mutations restricted the ability of HIV-1 envelope to localize on the cell membrane and thus markedly impaired virus assembly. The HIV-1 assembly defect could be overcome in trans if site-specific mutants were packaged in HeLa cells constitutively producing wild-type HIV-1 envelope glycoprotein. In addition to inefficient virus assembly, this mutation impaired the ability of the virus to infect CD4+ T cells, but did not affect CD4-independent infection of muscle cells. These results suggest additional functions of posttranslational modification in virus replication (i.e., envelope glycoprotein transport). Given that such modifications can restrict CD4-mediated uptake without affecting CD4-independent uptake, variations in posttranslational env processing between different HIV-1 genotypes may affect virus tropism in vivo." @default.
• W1978390640 created "2016-06-24" @default.
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• W1978390640 date "1991-06-01" @default.
• W1978390640 modified "2023-09-24" @default.
• W1978390640 title "Posttranslational Modifications within the HIV-1 Envelope Glycoprotein Which Restrict Virus Assembly and CD4-Dependent Infection" @default.
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• W1978390640 doi "https://doi.org/10.1089/aid.1991.7.501" @default.
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