FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978390844> ?p ?o ?g. }

• W1978390844 endingPage "672" @default.
• W1978390844 startingPage "664" @default.
• W1978390844 abstract "At present, the pharmacotherapy of Parkinson's disease (PD) consists mainly of L-dihydroxyphenylalanine (L-DOPA) and/or dopamine D2 receptor agonist. However, in general the clinical efficacy of D2 agonists is less than that of L-DOPA. Therefore, attention is being focussed on the role of the D1 receptor as a target for therapeutic intervention in PD. Recently, we reported that SKF 81297 is a selective D1 agonist that stimulates motor behavior of unilaterally MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine)-lesioned rhesus monkeys. Presently, we studied the effect of coadministration of SKF 81297 and the D2 agonist LY 171555 using the same model of PD. Coadministration of behaviorally active doses of SKF 81297 (0.3 mg/kg) and LY 171555 (0.01 mg/kg) resulted in a prolongation of the motor stimulation induced by either of the drugs alone. Neither administration of SKF 81297, in a dose of 0.03 mg/kg, nor of LY 171555, in a dose of 0.003 mg/kg, were behaviorally active, whereas the combined administration of these compounds induced a significant stimulation of motor behavior. These data suggest that (a) D1 receptor stimulation will prove to be useful in the treatment of PD and (b) better therapeutic results will be obtained by simultaneous stimulation of D1 and D2 receptors as compared with stimulation of both receptors alone." @default.
• W1978390844 created "2016-06-24" @default.
• W1978390844 creator A5017091939 @default.
• W1978390844 creator A5018932159 @default.
• W1978390844 creator A5020122101 @default.
• W1978390844 creator A5041925519 @default.
• W1978390844 creator A5088432855 @default.
• W1978390844 creator A5089717369 @default.
• W1978390844 date "1994-01-01" @default.
• W1978390844 modified "2023-10-17" @default.
• W1978390844 title "The dopamine D1 agonist SKF 81297 and the dopamine D2 agonist LY 171555 act synergistically to stimulate motor behavior of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-lesioned parkinsonian rhesus monkeys" @default.
• W1978390844 cites W1973512436 @default.
• W1978390844 cites W1976621129 @default.
• W1978390844 cites W1976856793 @default.
• W1978390844 cites W1977314903 @default.
• W1978390844 cites W1982176417 @default.
• W1978390844 cites W1985473339 @default.
• W1978390844 cites W1986090218 @default.
• W1978390844 cites W1987193373 @default.
• W1978390844 cites W1996552241 @default.
• W1978390844 cites W1996846600 @default.
• W1978390844 cites W2000550088 @default.
• W1978390844 cites W2002872111 @default.
• W1978390844 cites W2007696968 @default.
• W1978390844 cites W2010299478 @default.
• W1978390844 cites W2023231795 @default.
• W1978390844 cites W2024342346 @default.
• W1978390844 cites W2026114626 @default.
• W1978390844 cites W2026351748 @default.
• W1978390844 cites W2030905853 @default.
• W1978390844 cites W2031240835 @default.
• W1978390844 cites W2039724227 @default.
• W1978390844 cites W2047619967 @default.
• W1978390844 cites W2048713536 @default.
• W1978390844 cites W2048770548 @default.
• W1978390844 cites W2051414078 @default.
• W1978390844 cites W2057788173 @default.
• W1978390844 cites W2060790782 @default.
• W1978390844 cites W2061853672 @default.
• W1978390844 cites W2072822407 @default.
• W1978390844 cites W2077108130 @default.
• W1978390844 cites W2077672282 @default.
• W1978390844 cites W2082183427 @default.
• W1978390844 cites W2082388551 @default.
• W1978390844 cites W2083583704 @default.
• W1978390844 cites W2086013684 @default.
• W1978390844 cites W2089154427 @default.
• W1978390844 cites W2091813848 @default.
• W1978390844 cites W2092752413 @default.
• W1978390844 cites W2100100055 @default.
• W1978390844 cites W2100327073 @default.
• W1978390844 cites W2102541501 @default.
• W1978390844 cites W2144684127 @default.
• W1978390844 cites W2155175950 @default.
• W1978390844 cites W2173581666 @default.
• W1978390844 cites W2280366289 @default.
• W1978390844 cites W2336893408 @default.
• W1978390844 cites W2062839826 @default.
• W1978390844 doi "https://doi.org/10.1002/mds.870090613" @default.
• W1978390844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7845408" @default.
• W1978390844 hasPublicationYear "1994" @default.
• W1978390844 type Work @default.
• W1978390844 sameAs 1978390844 @default.
• W1978390844 citedByCount "40" @default.
• W1978390844 countsByYear W19783908442012 @default.
• W1978390844 countsByYear W19783908442013 @default.
• W1978390844 countsByYear W19783908442014 @default.
• W1978390844 countsByYear W19783908442015 @default.
• W1978390844 countsByYear W19783908442022 @default.
• W1978390844 countsByYear W19783908442023 @default.
• W1978390844 crossrefType "journal-article" @default.
• W1978390844 hasAuthorship W1978390844A5017091939 @default.
• W1978390844 hasAuthorship W1978390844A5018932159 @default.
• W1978390844 hasAuthorship W1978390844A5020122101 @default.
• W1978390844 hasAuthorship W1978390844A5041925519 @default.
• W1978390844 hasAuthorship W1978390844A5088432855 @default.
• W1978390844 hasAuthorship W1978390844A5089717369 @default.
• W1978390844 hasConcept C120069818 @default.
• W1978390844 hasConcept C126322002 @default.
• W1978390844 hasConcept C137183658 @default.
• W1978390844 hasConcept C170493617 @default.
• W1978390844 hasConcept C185592680 @default.
• W1978390844 hasConcept C24998067 @default.
• W1978390844 hasConcept C2778258207 @default.
• W1978390844 hasConcept C2778674702 @default.
• W1978390844 hasConcept C2778938600 @default.
• W1978390844 hasConcept C44208683 @default.
• W1978390844 hasConcept C513476851 @default.
• W1978390844 hasConcept C71924100 @default.
• W1978390844 hasConcept C98274493 @default.
• W1978390844 hasConceptScore W1978390844C120069818 @default.
• W1978390844 hasConceptScore W1978390844C126322002 @default.
• W1978390844 hasConceptScore W1978390844C137183658 @default.
• W1978390844 hasConceptScore W1978390844C170493617 @default.
• W1978390844 hasConceptScore W1978390844C185592680 @default.
• W1978390844 hasConceptScore W1978390844C24998067 @default.
• W1978390844 hasConceptScore W1978390844C2778258207 @default.
• W1978390844 hasConceptScore W1978390844C2778674702 @default.

• next