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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978391071> ?p ?o ?g. }

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• W1978391071 abstract "A novel series of α4β2 nAChR agonists lacking common pyridine or its bioisosteric heterocycle have been disclosed. Essential pharmacophoric elements of the series are exocyclic carbonyl moiety as a hydrogen bond acceptor and secondary amino group within diaza- or azabicyclic scaffold. Computer modeling studies suggested that molecular shape of the ligand also contributes to promotion of agonism. Proof of concept for improving working memory performance in a novel object recognition task has been demonstrated on a representative of the series, 3-propionyl-3,7-diazabicyclo[3.3.0]octane (34)." @default.
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• W1978391071 date "2013-07-01" @default.
• W1978391071 modified "2023-09-25" @default.
• W1978391071 title "Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor" @default.
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• W1978391071 doi "https://doi.org/10.1016/j.bmcl.2013.04.058" @default.
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