FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978391904> ?p ?o ?g. }

• W1978391904 endingPage "28" @default.
• W1978391904 startingPage "23" @default.
• W1978391904 abstract "<i>Background:</i> Impaired antioxidant defenses are implicated in neurodegenerative disease. The plasma levels of urate, a water-soluble antioxidant, are reduced in Alzheimer’s disease (AD). <i>Objective:</i> We aimed to test the hypotheses that high plasma urate at baseline is associated with: (1) a reduced rate of conversion from mild cognitive impairment (MCI) to AD and (2) a lower rate of cognitive decline in MCI. <i>Methods:</i> Plasma urate was obtained at baseline from 747 participants in a 3-year, randomized, double-blind, placebo-controlled study of donepezil, vitamin E or placebo for delaying the progression of MCI to AD.The association between baseline urate and conversion from MCI to AD was examined by Cox proportional hazards regression. The relationship between baseline urate and cognitive change on the cognitive subscale of the Alzheimer’s Disease Assessment Scale was evaluated by longitudinal analysis. <i>Results:</i> Baseline plasma urate was not associated with the rate of conversion of MCI to AD. In the placebo arm, high plasma urate was related to a slower rate of cognitive decline over 3 years, although this was not reproduced in the other treatment arms. <i>Conclusion:</i> While plasma urate levels did not predict the progression of MCI to AD, high urate may be associated with a reduced rate of cognitive decline in MCI patients not treated with donepezil or vitamin E. The results support the investigation of biomarkers of antioxidant status as risk factors for cognitive decline in MCI." @default.
• W1978391904 created "2016-06-24" @default.
• W1978391904 creator A5020862440 @default.
• W1978391904 creator A5028236243 @default.
• W1978391904 creator A5034225628 @default.
• W1978391904 creator A5040374029 @default.
• W1978391904 creator A5041777746 @default.
• W1978391904 creator A5068057129 @default.
• W1978391904 creator A5076158018 @default.
• W1978391904 creator A5077804573 @default.
• W1978391904 date "2008-11-05" @default.
• W1978391904 modified "2023-10-16" @default.
• W1978391904 title "Plasma Urate and Progression of Mild Cognitive Impairment" @default.
• W1978391904 cites W1953027527 @default.
• W1978391904 cites W1967203590 @default.
• W1978391904 cites W1993383247 @default.
• W1978391904 cites W1996252596 @default.
• W1978391904 cites W2026962766 @default.
• W1978391904 cites W2057047426 @default.
• W1978391904 cites W2097939227 @default.
• W1978391904 cites W2103163836 @default.
• W1978391904 cites W2107820540 @default.
• W1978391904 cites W2121816670 @default.
• W1978391904 cites W2127147704 @default.
• W1978391904 cites W2152845974 @default.
• W1978391904 cites W2153631628 @default.
• W1978391904 cites W2156884900 @default.
• W1978391904 cites W2163584809 @default.
• W1978391904 cites W2304267186 @default.
• W1978391904 cites W1963638095 @default.
• W1978391904 doi "https://doi.org/10.1159/000170883" @default.
• W1978391904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2745303" @default.
• W1978391904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19066433" @default.
• W1978391904 hasPublicationYear "2008" @default.
• W1978391904 type Work @default.
• W1978391904 sameAs 1978391904 @default.
• W1978391904 citedByCount "80" @default.
• W1978391904 countsByYear W19783919042012 @default.
• W1978391904 countsByYear W19783919042013 @default.
• W1978391904 countsByYear W19783919042014 @default.
• W1978391904 countsByYear W19783919042015 @default.
• W1978391904 countsByYear W19783919042016 @default.
• W1978391904 countsByYear W19783919042017 @default.
• W1978391904 countsByYear W19783919042018 @default.
• W1978391904 countsByYear W19783919042019 @default.
• W1978391904 countsByYear W19783919042020 @default.
• W1978391904 countsByYear W19783919042021 @default.
• W1978391904 countsByYear W19783919042022 @default.
• W1978391904 countsByYear W19783919042023 @default.
• W1978391904 crossrefType "journal-article" @default.
• W1978391904 hasAuthorship W1978391904A5020862440 @default.
• W1978391904 hasAuthorship W1978391904A5028236243 @default.
• W1978391904 hasAuthorship W1978391904A5034225628 @default.
• W1978391904 hasAuthorship W1978391904A5040374029 @default.
• W1978391904 hasAuthorship W1978391904A5041777746 @default.
• W1978391904 hasAuthorship W1978391904A5068057129 @default.
• W1978391904 hasAuthorship W1978391904A5076158018 @default.
• W1978391904 hasAuthorship W1978391904A5077804573 @default.
• W1978391904 hasBestOaLocation W19783919041 @default.
• W1978391904 hasConcept C118552586 @default.
• W1978391904 hasConcept C126322002 @default.
• W1978391904 hasConcept C134018914 @default.
• W1978391904 hasConcept C142724271 @default.
• W1978391904 hasConcept C15744967 @default.
• W1978391904 hasConcept C169900460 @default.
• W1978391904 hasConcept C204787440 @default.
• W1978391904 hasConcept C27081682 @default.
• W1978391904 hasConcept C2779134260 @default.
• W1978391904 hasConcept C2779483572 @default.
• W1978391904 hasConcept C2779881121 @default.
• W1978391904 hasConcept C2780904820 @default.
• W1978391904 hasConcept C2984863031 @default.
• W1978391904 hasConcept C502032728 @default.
• W1978391904 hasConcept C71924100 @default.
• W1978391904 hasConceptScore W1978391904C118552586 @default.
• W1978391904 hasConceptScore W1978391904C126322002 @default.
• W1978391904 hasConceptScore W1978391904C134018914 @default.
• W1978391904 hasConceptScore W1978391904C142724271 @default.
• W1978391904 hasConceptScore W1978391904C15744967 @default.
• W1978391904 hasConceptScore W1978391904C169900460 @default.
• W1978391904 hasConceptScore W1978391904C204787440 @default.
• W1978391904 hasConceptScore W1978391904C27081682 @default.
• W1978391904 hasConceptScore W1978391904C2779134260 @default.
• W1978391904 hasConceptScore W1978391904C2779483572 @default.
• W1978391904 hasConceptScore W1978391904C2779881121 @default.
• W1978391904 hasConceptScore W1978391904C2780904820 @default.
• W1978391904 hasConceptScore W1978391904C2984863031 @default.
• W1978391904 hasConceptScore W1978391904C502032728 @default.
• W1978391904 hasConceptScore W1978391904C71924100 @default.
• W1978391904 hasIssue "1-2" @default.
• W1978391904 hasLocation W19783919041 @default.
• W1978391904 hasLocation W19783919042 @default.
• W1978391904 hasLocation W19783919043 @default.
• W1978391904 hasLocation W19783919044 @default.
• W1978391904 hasOpenAccess W1978391904 @default.
• W1978391904 hasPrimaryLocation W19783919041 @default.
• W1978391904 hasRelatedWork W1963583371 @default.
• W1978391904 hasRelatedWork W1979139803 @default.

• next