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- W1978392076 abstract "Background Interstitial cells of Cajal associated with the submuscular plexus (ICC-SMP) generate omnipresent slow-wave activity in the colon and are associated with prominent motor patterns. Our aim was to investigate colon motor dysfunction in W/Wv mice in which the ICC are reportedly reduced. Methods Whole organ colon motility was studied using spatio-temporal mapping; immunohistochemical staining was carried out for c-Kit and Ano1; calcium imaging was applied to ICC-SMP. Key Results Discrepancies between Ano1 and c-Kit staining were found in both wild-type and W/Wv colon. ICC-SMP were reduced to ~50% in the W/Wv mouse colon according to c-Kit immunohistochemistry, but Ano1 staining indicated a normal network of ICC-SMP. The latter was consistent with rhythmic calcium transients occurring at the submucosal border of the colon in W/Wv mice, similar to the rhythmic transients in wild-type ICC-SMP. Furthermore, the motor pattern associated with ICC-SMP pacemaking, the so-called ‘ripples’ were normal in the W/Wv colon. Conclusions & Inferences c-Kit is not a reliable marker for quantifying ICC-SMP in the mouse colon. Ano1 staining revealed a normal network of ICC-SMP consistent with the presence of a normal ‘ripples’ motor pattern. We detected a class of Ano1 positive c-Kit negative cells that do not depend on Kit expression for maintenance, a feature shared with ICC progenitors." @default.
- W1978392076 created "2016-06-24" @default.
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- W1978392076 date "2014-07-14" @default.
- W1978392076 modified "2023-10-16" @default.
- W1978392076 title "Discrepancies between c-Kit positive and Ano1 positive ICC-SMP in theW/Wvand wild-type mouse colon; relationships with motor patterns and calcium transients" @default.
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- W1978392076 doi "https://doi.org/10.1111/nmo.12395" @default.
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