Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978392778> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1978392778 endingPage "2866" @default.
- W1978392778 startingPage "2859" @default.
- W1978392778 abstract "1-Methylpyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones 4, synthesized in good to excellent yields, were designed as novel alkylating agents because of their peculiar chemical behavior. All derivatives showed antiproliferative activity against more than 50 types of tumor cell lines with GI(50) reaching sub-micromolar values. SAR studies revealed that the presence of a chlorine atom is well-tolerated in both positions 8 and 9, whereas in the case of the methyl group, switching from the 8 to the 9 position gives rise to the most active compound of the series, 4g, either for the number of cell lines inhibited and for selectivity against leukaemia and renal cancer subpanels. COMPARE and 3D-MIND computations indicate, for compounds 4, an activity profile analogous to rifamycins and cytidine analogues." @default.
- W1978392778 created "2016-06-24" @default.
- W1978392778 creator A5010433779 @default.
- W1978392778 creator A5020869548 @default.
- W1978392778 creator A5049445439 @default.
- W1978392778 creator A5052325016 @default.
- W1978392778 creator A5065520810 @default.
- W1978392778 creator A5070066300 @default.
- W1978392778 creator A5082935867 @default.
- W1978392778 creator A5090617571 @default.
- W1978392778 date "2005-03-15" @default.
- W1978392778 modified "2023-10-16" @default.
- W1978392778 title "1-Methyl-3<i>H</i>-pyrazolo[1,2-<i>a</i>]benzo[1,2,3,4]tetrazin-3-ones. Design, Synthesis, and Biological Activity of New Antitumor Agents" @default.
- W1978392778 cites W2029685200 @default.
- W1978392778 cites W2098426299 @default.
- W1978392778 cites W2167713837 @default.
- W1978392778 cites W2409084636 @default.
- W1978392778 cites W88876866 @default.
- W1978392778 doi "https://doi.org/10.1021/jm049075u" @default.
- W1978392778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15828824" @default.
- W1978392778 hasPublicationYear "2005" @default.
- W1978392778 type Work @default.
- W1978392778 sameAs 1978392778 @default.
- W1978392778 citedByCount "11" @default.
- W1978392778 countsByYear W19783927782013 @default.
- W1978392778 countsByYear W19783927782014 @default.
- W1978392778 countsByYear W19783927782016 @default.
- W1978392778 countsByYear W19783927782017 @default.
- W1978392778 countsByYear W19783927782018 @default.
- W1978392778 countsByYear W19783927782021 @default.
- W1978392778 countsByYear W19783927782022 @default.
- W1978392778 countsByYear W19783927782023 @default.
- W1978392778 crossrefType "journal-article" @default.
- W1978392778 hasAuthorship W1978392778A5010433779 @default.
- W1978392778 hasAuthorship W1978392778A5020869548 @default.
- W1978392778 hasAuthorship W1978392778A5049445439 @default.
- W1978392778 hasAuthorship W1978392778A5052325016 @default.
- W1978392778 hasAuthorship W1978392778A5065520810 @default.
- W1978392778 hasAuthorship W1978392778A5070066300 @default.
- W1978392778 hasAuthorship W1978392778A5082935867 @default.
- W1978392778 hasAuthorship W1978392778A5090617571 @default.
- W1978392778 hasConcept C118792377 @default.
- W1978392778 hasConcept C121608353 @default.
- W1978392778 hasConcept C126322002 @default.
- W1978392778 hasConcept C161790260 @default.
- W1978392778 hasConcept C181199279 @default.
- W1978392778 hasConcept C185592680 @default.
- W1978392778 hasConcept C193042331 @default.
- W1978392778 hasConcept C202751555 @default.
- W1978392778 hasConcept C2777752112 @default.
- W1978392778 hasConcept C2781184954 @default.
- W1978392778 hasConcept C2994372470 @default.
- W1978392778 hasConcept C54355233 @default.
- W1978392778 hasConcept C55493867 @default.
- W1978392778 hasConcept C71240020 @default.
- W1978392778 hasConcept C71924100 @default.
- W1978392778 hasConcept C81885089 @default.
- W1978392778 hasConcept C86803240 @default.
- W1978392778 hasConcept C96232424 @default.
- W1978392778 hasConceptScore W1978392778C118792377 @default.
- W1978392778 hasConceptScore W1978392778C121608353 @default.
- W1978392778 hasConceptScore W1978392778C126322002 @default.
- W1978392778 hasConceptScore W1978392778C161790260 @default.
- W1978392778 hasConceptScore W1978392778C181199279 @default.
- W1978392778 hasConceptScore W1978392778C185592680 @default.
- W1978392778 hasConceptScore W1978392778C193042331 @default.
- W1978392778 hasConceptScore W1978392778C202751555 @default.
- W1978392778 hasConceptScore W1978392778C2777752112 @default.
- W1978392778 hasConceptScore W1978392778C2781184954 @default.
- W1978392778 hasConceptScore W1978392778C2994372470 @default.
- W1978392778 hasConceptScore W1978392778C54355233 @default.
- W1978392778 hasConceptScore W1978392778C55493867 @default.
- W1978392778 hasConceptScore W1978392778C71240020 @default.
- W1978392778 hasConceptScore W1978392778C71924100 @default.
- W1978392778 hasConceptScore W1978392778C81885089 @default.
- W1978392778 hasConceptScore W1978392778C86803240 @default.
- W1978392778 hasConceptScore W1978392778C96232424 @default.
- W1978392778 hasIssue "8" @default.
- W1978392778 hasLocation W19783927781 @default.
- W1978392778 hasLocation W19783927782 @default.
- W1978392778 hasOpenAccess W1978392778 @default.
- W1978392778 hasPrimaryLocation W19783927781 @default.
- W1978392778 hasRelatedWork W1978392778 @default.
- W1978392778 hasRelatedWork W2019325755 @default.
- W1978392778 hasRelatedWork W2047534689 @default.
- W1978392778 hasRelatedWork W2054073249 @default.
- W1978392778 hasRelatedWork W2123829225 @default.
- W1978392778 hasRelatedWork W2128093567 @default.
- W1978392778 hasRelatedWork W2168866047 @default.
- W1978392778 hasRelatedWork W2624676977 @default.
- W1978392778 hasRelatedWork W2803607030 @default.
- W1978392778 hasRelatedWork W3007446011 @default.
- W1978392778 hasVolume "48" @default.
- W1978392778 isParatext "false" @default.
- W1978392778 isRetracted "false" @default.
- W1978392778 magId "1978392778" @default.
- W1978392778 workType "article" @default.