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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978392910> ?p ?o ?g. }

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• W1978392910 abstract "p-amidinophenylmethylphosphinic acid (AMPA) was designed, synthesized and crystallized in complex with trypsin to study interactions with the oxyanion hole at the S1 site. In comparison to benzamidine, AMPA shows improved activity, which the crystal structure demonstrates to result from hydrogen bonds between the negatively charged phosphinic acid group and the catalytic residues at the oxyanion hole." @default.
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• W1978392910 date "2002-01-01" @default.
• W1978392910 modified "2023-10-14" @default.
• W1978392910 title "An oxyanion-Hole selective serine protease inhibitor in complex with trypsin" @default.
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• W1978392910 doi "https://doi.org/10.1016/s0968-0896(01)00259-0" @default.
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