Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978394424> ?p ?o ?g. }
- W1978394424 endingPage "294" @default.
- W1978394424 startingPage "283" @default.
- W1978394424 abstract "Methods controlling tissue fibrosis are classified into those specifically inhibiting various metabolic aspects of collagen selectively in the injured tissue (ascorbic acid deficiency, effect of agent chelating Fe2+, proline analogs, lathyrogens). The most promising method seems to be the blocking of crosslinks formation among collagen molecules by β-aminopropionitrile, a competitive inhibitor of a crosslinking enzyme, lysyl oxidase. The second group of methods is called nonspecific, as they affect any stage of inflammatory process preceding the activation of fibroblasts. The importance of activated macrophages in the stimulation of fibroblast is discussed. Finally, a new concept is proposed, indicating the function of zinc ions in the control of the integrity of biomembrances, tissue reactivity to noxious agents. It is suggested that zinc may control NADPH dependent lipid peroxidation at the membrane level by inhibiting NADPH oxidase activity. The implication of these ideas to lung fibrosis induced by silica or asbestos is discussed." @default.
- W1978394424 created "2016-06-24" @default.
- W1978394424 creator A5017469879 @default.
- W1978394424 date "1974-12-01" @default.
- W1978394424 modified "2023-09-26" @default.
- W1978394424 title "Pharmacology of fibrosis and tissue injury" @default.
- W1978394424 cites W112314493 @default.
- W1978394424 cites W157678035 @default.
- W1978394424 cites W1788381492 @default.
- W1978394424 cites W1966277412 @default.
- W1978394424 cites W1969347482 @default.
- W1978394424 cites W1969400088 @default.
- W1978394424 cites W1973751677 @default.
- W1978394424 cites W1982160831 @default.
- W1978394424 cites W1984727500 @default.
- W1978394424 cites W1997193502 @default.
- W1978394424 cites W1997599157 @default.
- W1978394424 cites W2023655807 @default.
- W1978394424 cites W2028394231 @default.
- W1978394424 cites W2028678638 @default.
- W1978394424 cites W2032781979 @default.
- W1978394424 cites W2034954635 @default.
- W1978394424 cites W2043202364 @default.
- W1978394424 cites W2048502402 @default.
- W1978394424 cites W2055026787 @default.
- W1978394424 cites W2055193586 @default.
- W1978394424 cites W2056374445 @default.
- W1978394424 cites W2065250371 @default.
- W1978394424 cites W2073980243 @default.
- W1978394424 cites W2074620369 @default.
- W1978394424 cites W2075807865 @default.
- W1978394424 cites W2082481602 @default.
- W1978394424 cites W2092495204 @default.
- W1978394424 cites W2111031157 @default.
- W1978394424 cites W2143914403 @default.
- W1978394424 cites W2221329215 @default.
- W1978394424 cites W2317547034 @default.
- W1978394424 cites W2322575589 @default.
- W1978394424 cites W2330626934 @default.
- W1978394424 cites W2330721714 @default.
- W1978394424 cites W2395643266 @default.
- W1978394424 cites W2407195947 @default.
- W1978394424 cites W2409682667 @default.
- W1978394424 cites W2461349698 @default.
- W1978394424 cites W279352032 @default.
- W1978394424 cites W3155699657 @default.
- W1978394424 cites W34663017 @default.
- W1978394424 cites W4239186876 @default.
- W1978394424 cites W4240624404 @default.
- W1978394424 cites W66480186 @default.
- W1978394424 cites W2406089289 @default.
- W1978394424 doi "https://doi.org/10.1289/ehp.749283" @default.
- W1978394424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1475407" @default.
- W1978394424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4377875" @default.
- W1978394424 hasPublicationYear "1974" @default.
- W1978394424 type Work @default.
- W1978394424 sameAs 1978394424 @default.
- W1978394424 citedByCount "21" @default.
- W1978394424 countsByYear W19783944242015 @default.
- W1978394424 crossrefType "journal-article" @default.
- W1978394424 hasAuthorship W1978394424A5017469879 @default.
- W1978394424 hasBestOaLocation W19783944241 @default.
- W1978394424 hasConcept C134018914 @default.
- W1978394424 hasConcept C142724271 @default.
- W1978394424 hasConcept C181199279 @default.
- W1978394424 hasConcept C185592680 @default.
- W1978394424 hasConcept C193143273 @default.
- W1978394424 hasConcept C202751555 @default.
- W1978394424 hasConcept C203014093 @default.
- W1978394424 hasConcept C24998067 @default.
- W1978394424 hasConcept C2778250585 @default.
- W1978394424 hasConcept C2779719074 @default.
- W1978394424 hasConcept C2780269544 @default.
- W1978394424 hasConcept C2780381497 @default.
- W1978394424 hasConcept C2780559512 @default.
- W1978394424 hasConcept C2780829032 @default.
- W1978394424 hasConcept C2781244666 @default.
- W1978394424 hasConcept C2986274086 @default.
- W1978394424 hasConcept C31903555 @default.
- W1978394424 hasConcept C55493867 @default.
- W1978394424 hasConcept C71924100 @default.
- W1978394424 hasConcept C86803240 @default.
- W1978394424 hasConcept C95444343 @default.
- W1978394424 hasConcept C98274493 @default.
- W1978394424 hasConceptScore W1978394424C134018914 @default.
- W1978394424 hasConceptScore W1978394424C142724271 @default.
- W1978394424 hasConceptScore W1978394424C181199279 @default.
- W1978394424 hasConceptScore W1978394424C185592680 @default.
- W1978394424 hasConceptScore W1978394424C193143273 @default.
- W1978394424 hasConceptScore W1978394424C202751555 @default.
- W1978394424 hasConceptScore W1978394424C203014093 @default.
- W1978394424 hasConceptScore W1978394424C24998067 @default.
- W1978394424 hasConceptScore W1978394424C2778250585 @default.
- W1978394424 hasConceptScore W1978394424C2779719074 @default.
- W1978394424 hasConceptScore W1978394424C2780269544 @default.
- W1978394424 hasConceptScore W1978394424C2780381497 @default.
- W1978394424 hasConceptScore W1978394424C2780559512 @default.
- W1978394424 hasConceptScore W1978394424C2780829032 @default.