FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978394922> ?p ?o ?g. }

• W1978394922 endingPage "866" @default.
• W1978394922 startingPage "861" @default.
• W1978394922 abstract "The endogenous cannabinoid system appears to serve vascular, neurological, immunological, and reproductive functions. The identification of 2-arachidonylglycerol (2-AG) as an endogenous ligand for the central (CB1) and peripheral (CB2) cannabinoid receptors has prompted interest in enzymes capable of modifying or inactivating this endocannabinoid. Porcine leukocyte 12-liopoxygenase (12-LOX) oxygenated 2-AG to the 2-glyceryl ester of 12(S)-hydroperoxyeicosa-5,8,10,14-tetraenoic acid (12-HPETE-G). The k(cat)/K(M) for oxygenation of 2-AG was 40% of the value for arachidonic acid. In contrast to the results with leukocyte 12-LOX, 2-AG oxygenation was not detected with platelet-type 12-LOX. Among a series of structurally related arachidonyl esters, 2-AG served as the preferential substrate for leukocyte 12-LOX. 12(S)-Hydroxyeicosa-5,8,10,14-tetraenoic acid glyceryl ester (12-HETE-G) was produced following addition of 2-AG to COS-7 cells transiently transfected with leukocyte 12-LOX. These results demonstrate that leukocyte-type 12-LOX efficiently oxidizes 2-AG in vitro and in intact cells, suggesting a role for this oxygenase in the endogenous cannabinoid system." @default.
• W1978394922 created "2016-06-24" @default.
• W1978394922 creator A5019841142 @default.
• W1978394922 creator A5038479973 @default.
• W1978394922 creator A5065485341 @default.
• W1978394922 creator A5089031929 @default.
• W1978394922 date "2000-12-30" @default.
• W1978394922 modified "2023-10-16" @default.
• W1978394922 title "Selective Oxygenation of the Endocannabinoid 2-Arachidonylglycerol by Leukocyte-Type 12-Lipoxygenase" @default.
• W1978394922 cites W1833773653 @default.
• W1978394922 cites W2004704496 @default.
• W1978394922 cites W2023462478 @default.
• W1978394922 cites W2024653583 @default.
• W1978394922 cites W2074203890 @default.
• W1978394922 cites W2075336999 @default.
• W1978394922 cites W2086458197 @default.
• W1978394922 cites W2089573633 @default.
• W1978394922 cites W2102941373 @default.
• W1978394922 cites W2108792509 @default.
• W1978394922 cites W2121449652 @default.
• W1978394922 cites W2125720771 @default.
• W1978394922 cites W2157065782 @default.
• W1978394922 doi "https://doi.org/10.1021/bi002303b" @default.
• W1978394922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/812558" @default.
• W1978394922 hasPublicationYear "2000" @default.
• W1978394922 type Work @default.
• W1978394922 sameAs 1978394922 @default.
• W1978394922 citedByCount "78" @default.
• W1978394922 countsByYear W19783949222012 @default.
• W1978394922 countsByYear W19783949222013 @default.
• W1978394922 countsByYear W19783949222014 @default.
• W1978394922 countsByYear W19783949222015 @default.
• W1978394922 countsByYear W19783949222016 @default.
• W1978394922 countsByYear W19783949222017 @default.
• W1978394922 countsByYear W19783949222018 @default.
• W1978394922 countsByYear W19783949222019 @default.
• W1978394922 countsByYear W19783949222020 @default.
• W1978394922 countsByYear W19783949222021 @default.
• W1978394922 countsByYear W19783949222022 @default.
• W1978394922 countsByYear W19783949222023 @default.
• W1978394922 crossrefType "journal-article" @default.
• W1978394922 hasAuthorship W1978394922A5019841142 @default.
• W1978394922 hasAuthorship W1978394922A5038479973 @default.
• W1978394922 hasAuthorship W1978394922A5065485341 @default.
• W1978394922 hasAuthorship W1978394922A5089031929 @default.
• W1978394922 hasConcept C116569031 @default.
• W1978394922 hasConcept C148001335 @default.
• W1978394922 hasConcept C16613235 @default.
• W1978394922 hasConcept C170493617 @default.
• W1978394922 hasConcept C181199279 @default.
• W1978394922 hasConcept C185592680 @default.
• W1978394922 hasConcept C18903297 @default.
• W1978394922 hasConcept C2777289219 @default.
• W1978394922 hasConcept C2778078955 @default.
• W1978394922 hasConcept C2778938600 @default.
• W1978394922 hasConcept C2779783865 @default.
• W1978394922 hasConcept C2780857362 @default.
• W1978394922 hasConcept C2780871563 @default.
• W1978394922 hasConcept C46721173 @default.
• W1978394922 hasConcept C55493867 @default.
• W1978394922 hasConcept C71240020 @default.
• W1978394922 hasConcept C86803240 @default.
• W1978394922 hasConcept C98274493 @default.
• W1978394922 hasConceptScore W1978394922C116569031 @default.
• W1978394922 hasConceptScore W1978394922C148001335 @default.
• W1978394922 hasConceptScore W1978394922C16613235 @default.
• W1978394922 hasConceptScore W1978394922C170493617 @default.
• W1978394922 hasConceptScore W1978394922C181199279 @default.
• W1978394922 hasConceptScore W1978394922C185592680 @default.
• W1978394922 hasConceptScore W1978394922C18903297 @default.
• W1978394922 hasConceptScore W1978394922C2777289219 @default.
• W1978394922 hasConceptScore W1978394922C2778078955 @default.
• W1978394922 hasConceptScore W1978394922C2778938600 @default.
• W1978394922 hasConceptScore W1978394922C2779783865 @default.
• W1978394922 hasConceptScore W1978394922C2780857362 @default.
• W1978394922 hasConceptScore W1978394922C2780871563 @default.
• W1978394922 hasConceptScore W1978394922C46721173 @default.
• W1978394922 hasConceptScore W1978394922C55493867 @default.
• W1978394922 hasConceptScore W1978394922C71240020 @default.
• W1978394922 hasConceptScore W1978394922C86803240 @default.
• W1978394922 hasConceptScore W1978394922C98274493 @default.
• W1978394922 hasIssue "4" @default.
• W1978394922 hasLocation W19783949221 @default.
• W1978394922 hasLocation W19783949222 @default.
• W1978394922 hasOpenAccess W1978394922 @default.
• W1978394922 hasPrimaryLocation W19783949221 @default.
• W1978394922 hasRelatedWork W1594190119 @default.
• W1978394922 hasRelatedWork W1978394922 @default.
• W1978394922 hasRelatedWork W2023462478 @default.
• W1978394922 hasRelatedWork W2066350084 @default.
• W1978394922 hasRelatedWork W2077923363 @default.
• W1978394922 hasRelatedWork W2081432108 @default.
• W1978394922 hasRelatedWork W2088083175 @default.
• W1978394922 hasRelatedWork W2255328853 @default.
• W1978394922 hasRelatedWork W2581625712 @default.
• W1978394922 hasRelatedWork W3134922227 @default.
• W1978394922 hasVolume "40" @default.
• W1978394922 isParatext "false" @default.

• next