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- W1978395024 abstract "Rho family GTPases, including RhoA, Rac1, and Cdc42 as the most studied members, are master regulators of actin cytoskeletal organization. Rho GTPases control various aspects of the nervous system and are associated with a number of neuropsychiatric and neurodegenerative diseases. The activity of Rho GTPases is controlled by two families of regulators, guanine nucleotide exchange factors (GEFs) as the activators and GTPase-activating proteins (GAPs) as the inhibitors. Through coordinated regulation by GEFs and GAPs, Rho GTPases act as converging signaling molecules that convey different upstream signals in the nervous system. So far, more than 70 members of either GEFs or GAPs of Rho GTPases have been identified in mammals, but only a small subset of them have well-known functions. Thus, characterization of important GEFs and GAPs in the nervous system is crucial for the understanding of spatiotemporal dynamics of Rho GTPase activity in different neuronal functions. In this review, we summarize the current understanding of GEFs and GAPs for Rac1, with emphasis on the molecular function and disease implication of these regulators in the nervous system." @default.
- W1978395024 created "2016-06-24" @default.
- W1978395024 creator A5015641842 @default.
- W1978395024 creator A5022582976 @default.
- W1978395024 creator A5027551828 @default.
- W1978395024 creator A5073365758 @default.
- W1978395024 date "2015-01-01" @default.
- W1978395024 modified "2023-10-13" @default.
- W1978395024 title "Regulating Rac in the Nervous System: Molecular Function and Disease Implication of Rac GEFs and GAPs" @default.
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