FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978396088> ?p ?o ?g. }

• W1978396088 endingPage "532" @default.
• W1978396088 startingPage "522" @default.
• W1978396088 abstract "Background: Abdominal aortic aneurysms (AAAs) are associated with chronic inflammation, disruption of medial elastin, and increased local production of elastolytic matrix metalloproteinases (MMPs). The purpose of this study was to investigate how treatment with a hydroxamate-based MMP antagonist (RS 132908) might affect the development of experimental AAAs. Methods: Male Wistar rats underwent intraluminal perfusion of the abdominal aorta with 50 units of porcine pancreatic elastase followed by treatment for 14 days with RS 132908 (100 mg/kg/day subcutaneously; n = 8) or with vehicle alone (n = 6). The external aortic diameter (AD) was measured in millimeters before elastase perfusion and at death, with AAA defined as an increase in AD (ΔAD) of at least 100%. Aortic wall elastin and collagen concentrations were measured with assays for desmosine and hydroxyproline, and fixed aortic tissues were examined by light microscopy. Results: AAAs developed in all vehicle-treated rats, with a mean AD (± SE) that increased from 1.60 ± 0.03 mm before perfusion to 5.98 ± 1.02 mm on day 14 (ΔAD = 276.4 ± 67.7%). AAAs developed in only five of eight animals (62.5%) after MMP inhibition, with a mean AD that increased from 1.56 ± 0.05 mm to 3.59 ± 0.34 mm (ΔAD = 128.1 ± 18.7%; P < .05, vs vehicle). The overall inhibition of aortic dilatation attributable to RS 132908 was 53.6 ± 6.8%. Aortic wall desmosine fell by 85.4% in the vehicle-treated rats (1210.6 ± 87.8 pmol/sample to 176.7 ± 33.4 pmol/sample; P < .05) but only by 65.6% in the animals treated with RS 312908 (416.2 ± 120.5 pmol/sample). In contrast, hydroxyproline was not significantly affected by either elastase perfusion or drug treatment. Microscopic examination revealed the preservation of pericellular elastin and a greater degree of fibrocollagenous wall thickening after MMP inhibition, with no detectable difference in the extent of inflammation. Conclusions: Systemic MMP inhibition suppresses aneurysmal dilatation in the elastase-induced rodent model of AAA. Consistent with its direct inhibitory effect on various MMPs, RS 132908 promotes the preservation of aortic elastin and appears to enhance a profibrotic response within the aortic wall. Hydroxamate-based MMP antagonists may therefore be useful in the development of pharmacologic approaches to the suppression of AAAs. (J Vasc Surg 1999;29:522-32.)" @default.
• W1978396088 created "2016-06-24" @default.
• W1978396088 creator A5014107862 @default.
• W1978396088 creator A5021369727 @default.
• W1978396088 creator A5038622596 @default.
• W1978396088 creator A5045971985 @default.
• W1978396088 creator A5058896898 @default.
• W1978396088 creator A5064199032 @default.
• W1978396088 creator A5064498640 @default.
• W1978396088 creator A5069552147 @default.
• W1978396088 date "1999-03-01" @default.
• W1978396088 modified "2023-10-02" @default.
• W1978396088 title "Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908)" @default.
• W1978396088 cites W1543657232 @default.
• W1978396088 cites W1965445560 @default.
• W1978396088 cites W1970803892 @default.
• W1978396088 cites W1973061804 @default.
• W1978396088 cites W1973189198 @default.
• W1978396088 cites W1974238595 @default.
• W1978396088 cites W1974699483 @default.
• W1978396088 cites W1976562969 @default.
• W1978396088 cites W1978290957 @default.
• W1978396088 cites W1982904427 @default.
• W1978396088 cites W1990962135 @default.
• W1978396088 cites W1991901773 @default.
• W1978396088 cites W1995622858 @default.
• W1978396088 cites W2011339859 @default.
• W1978396088 cites W2015725632 @default.
• W1978396088 cites W2016203569 @default.
• W1978396088 cites W2023319309 @default.
• W1978396088 cites W2027181290 @default.
• W1978396088 cites W2029408064 @default.
• W1978396088 cites W2036842448 @default.
• W1978396088 cites W2042572296 @default.
• W1978396088 cites W2047110284 @default.
• W1978396088 cites W2058298189 @default.
• W1978396088 cites W2061041332 @default.
• W1978396088 cites W2063699934 @default.
• W1978396088 cites W2065530999 @default.
• W1978396088 cites W2067931227 @default.
• W1978396088 cites W2074881372 @default.
• W1978396088 cites W2078850591 @default.
• W1978396088 cites W2081117740 @default.
• W1978396088 cites W2084468122 @default.
• W1978396088 cites W2085775078 @default.
• W1978396088 cites W2091379422 @default.
• W1978396088 cites W2091637617 @default.
• W1978396088 cites W2094464913 @default.
• W1978396088 cites W2095250024 @default.
• W1978396088 cites W2125885739 @default.
• W1978396088 cites W2127350764 @default.
• W1978396088 cites W2152484902 @default.
• W1978396088 cites W2154559263 @default.
• W1978396088 cites W2155036039 @default.
• W1978396088 cites W2158228532 @default.
• W1978396088 cites W2169817950 @default.
• W1978396088 cites W3143448550 @default.
• W1978396088 cites W4300365946 @default.
• W1978396088 cites W4376567326 @default.
• W1978396088 cites W99975987 @default.
• W1978396088 doi "https://doi.org/10.1016/s0741-5214(99)70281-8" @default.
• W1978396088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10069917" @default.
• W1978396088 hasPublicationYear "1999" @default.
• W1978396088 type Work @default.
• W1978396088 sameAs 1978396088 @default.
• W1978396088 citedByCount "78" @default.
• W1978396088 countsByYear W19783960882012 @default.
• W1978396088 countsByYear W19783960882014 @default.
• W1978396088 countsByYear W19783960882015 @default.
• W1978396088 countsByYear W19783960882016 @default.
• W1978396088 countsByYear W19783960882017 @default.
• W1978396088 countsByYear W19783960882018 @default.
• W1978396088 countsByYear W19783960882019 @default.
• W1978396088 countsByYear W19783960882023 @default.
• W1978396088 crossrefType "journal-article" @default.
• W1978396088 hasAuthorship W1978396088A5014107862 @default.
• W1978396088 hasAuthorship W1978396088A5021369727 @default.
• W1978396088 hasAuthorship W1978396088A5038622596 @default.
• W1978396088 hasAuthorship W1978396088A5045971985 @default.
• W1978396088 hasAuthorship W1978396088A5058896898 @default.
• W1978396088 hasAuthorship W1978396088A5064199032 @default.
• W1978396088 hasAuthorship W1978396088A5064498640 @default.
• W1978396088 hasAuthorship W1978396088A5069552147 @default.
• W1978396088 hasBestOaLocation W19783960881 @default.
• W1978396088 hasConcept C109523444 @default.
• W1978396088 hasConcept C126322002 @default.
• W1978396088 hasConcept C134018914 @default.
• W1978396088 hasConcept C142724271 @default.
• W1978396088 hasConcept C146957229 @default.
• W1978396088 hasConcept C181199279 @default.
• W1978396088 hasConcept C185592680 @default.
• W1978396088 hasConcept C2776326425 @default.
• W1978396088 hasConcept C2777323849 @default.
• W1978396088 hasConcept C2779797417 @default.
• W1978396088 hasConcept C2779869378 @default.
• W1978396088 hasConcept C2779980429 @default.
• W1978396088 hasConcept C2780520971 @default.
• W1978396088 hasConcept C2780638554 @default.

• next