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• W1978401182 abstract "Aim: This study evaluated the hypothesis that physiological maturation affects cerebral artery smooth muscle–endothelial interactions involved in pressure-induced tone and alters the dimensional and biomechanical properties of small posterior cerebral arteries (PCA). Methods: Secondary branches of PCA from young (4–5 weeks old, n = 11), adult (14–16 weeks old, n = 11) and mature (44–47 weeks old, n = 11) male Sprague-Dawley rats were isolated, cannulated, pressurized and subjected to a range of intraluminal pressures (10–110 mmHg) to determine tone with and without pharmacologic nitric oxide synthase (NOS) inhibition. Measurements of passive lumen diameter and wall thickness as a function of pressure were used to determine changes in structure, distensibility and wall stress; histological analysis was performed on vessel cross-sections to assess collagen and elastin contents. Results: Although pressure-dependent tone decreased significantly during ageing, differences between groups were abolished by NOS inhibition. Vessel diameters increased in adult vs. young rats (at 90 mmHg, 233 ± 6.0 μm vs. 192 ± 4.5 μm; P < 0.05), possibly secondary to somatic growth. Further ageing was associated with reductions in lumen diameter (207 ± 6.5 μm; P < 0.05), increased wall and media thickness (and wall/lumen ratio) and cross-sectional area. Distensibility and wall collagen were unchanged, although elastin content was significantly reduced. Conclusions: Maturation is associated with differences in PCA dimensional properties that indicate a pattern of initial outward eutrophic, followed by inward hypertrophic remodelling. Functionally, the contribution of basal NO increases with age in a way that reduces pressure-dependent tone and diminishes vasodilator reserve." @default.
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• W1978401182 date "2012-01-25" @default.
• W1978401182 modified "2023-10-17" @default.
• W1978401182 title "Maturation is associated with changes in rat cerebral artery structure, biomechanical properties and tone" @default.
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• W1978401182 doi "https://doi.org/10.1111/j.1748-1716.2011.02406.x" @default.
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