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• W1978409622 abstract "The effects of lesioning mesostriatal dopamine projections or striatal neurons on tachykinin binding in the basal ganglia were assessed in the rat. 6-Hydroxydopamine lesions of the medial forebrain bundle destroyed striatal dopamine terminals as assessed by [3H]mazindol autoradiography, but did not significantly affect the binding of NK-1 ([3H][Sar9, Met(O2)11]substance P) or NK-3 ([3H]senktide) tachykinin ligands in the striatum. 6-Hydroxydopamine lesions significantly reduced NK-3 binding in the substantia nigra pars compacta, but not the ventral tegmental area. In contrast, striatal quinolinic acid lesions reduced both NK-1 and NK-3 binding in the striatum, but failed to affect NK-3 binding in the substantia nigra. These findings suggest that both NK-1 and NK-3 receptors within the striatum are predominantly post-synaptic with respect to dopamine neurons, whereas nigral NK-3 receptors are located on dopaminergic neurons." @default.
• W1978409622 created "2016-06-24" @default.
• W1978409622 creator A5066908279 @default.
• W1978409622 date "1994-05-01" @default.
• W1978409622 modified "2023-09-27" @default.
• W1978409622 title "Localization of striatal and nigral tachykinin receptors in the rat" @default.
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• W1978409622 doi "https://doi.org/10.1016/0006-8993(94)90052-3" @default.
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