FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978412174> ?p ?o ?g. }

• W1978412174 endingPage "6131" @default.
• W1978412174 startingPage "6131" @default.
• W1978412174 abstract "To investigate the safety and preliminary efficacy of OT-551, a disubstituted hydroxylamine with antioxidant properties, for the treatment of geographic atrophy (GA), the advanced atrophic form of age-related macular degeneration (AMD).The study was a single-center, open-label phase II trial, enrolling 10 participants with bilateral GA. Topical 0.45% OT-551 was administered in one randomly assigned eye three times daily for 2 years. Safety measures were assessed by complete ophthalmic examination, fundus photography, and review of symptoms. The primary efficacy outcome measure was the change in best corrected visual acuity at 24 months. Secondary efficacy measures included changes in area of GA, contrast sensitivity, microperimetry measurements, and total drusen area from baseline.Study drug was well tolerated and was associated with few adverse events. The mean change in BCVA at 2 years was +0.2 ± 13.3 letters in the study eyes and -11.3 ± 7.6 letters in fellow eyes (P = 0.0259). However, no statistically significant differences were found between the study and fellow eyes for all other secondary outcome measures.OT-551 was well tolerated by study participants and was not associated with any serious adverse effects. Efficacy measurements in this small study indicate a possible effect in maintaining visual acuity. However, the absence of significant effects on other outcomes measures in this study suggests that OT-551, in the current concentration and mode of delivery, may have limited or no benefit as a treatment for GA (ClinicalTrials.gov number, NCT00306488)." @default.
• W1978412174 created "2016-06-24" @default.
• W1978412174 creator A5004857974 @default.
• W1978412174 creator A5010280456 @default.
• W1978412174 creator A5017028738 @default.
• W1978412174 creator A5020628503 @default.
• W1978412174 creator A5040200688 @default.
• W1978412174 creator A5041500763 @default.
• W1978412174 creator A5043372772 @default.
• W1978412174 creator A5066334310 @default.
• W1978412174 creator A5068302775 @default.
• W1978412174 creator A5090802305 @default.
• W1978412174 date "2010-12-01" @default.
• W1978412174 modified "2023-10-06" @default.
• W1978412174 title "Treatment of Geographic Atrophy by the Topical Administration of OT-551: Results of a Phase II Clinical Trial" @default.
• W1978412174 cites W1541005345 @default.
• W1978412174 cites W1543801259 @default.
• W1978412174 cites W15885275 @default.
• W1978412174 cites W1967443341 @default.
• W1978412174 cites W1970714860 @default.
• W1978412174 cites W1977855901 @default.
• W1978412174 cites W1981265260 @default.
• W1978412174 cites W1993599928 @default.
• W1978412174 cites W1996821302 @default.
• W1978412174 cites W200886222 @default.
• W1978412174 cites W2010942158 @default.
• W1978412174 cites W2011876741 @default.
• W1978412174 cites W2020025884 @default.
• W1978412174 cites W2021027890 @default.
• W1978412174 cites W2035228551 @default.
• W1978412174 cites W2036755683 @default.
• W1978412174 cites W2044448390 @default.
• W1978412174 cites W2052064127 @default.
• W1978412174 cites W2054857117 @default.
• W1978412174 cites W2058344658 @default.
• W1978412174 cites W2062520785 @default.
• W1978412174 cites W2064170412 @default.
• W1978412174 cites W2070693350 @default.
• W1978412174 cites W2082991370 @default.
• W1978412174 cites W2091428334 @default.
• W1978412174 cites W2104421967 @default.
• W1978412174 cites W2113310876 @default.
• W1978412174 cites W2122067959 @default.
• W1978412174 cites W2136501493 @default.
• W1978412174 cites W2136537767 @default.
• W1978412174 cites W2144839999 @default.
• W1978412174 cites W2155204921 @default.
• W1978412174 cites W2155236757 @default.
• W1978412174 cites W2315512556 @default.
• W1978412174 cites W2343638550 @default.
• W1978412174 cites W2401288801 @default.
• W1978412174 cites W2597267452 @default.
• W1978412174 cites W2598520882 @default.
• W1978412174 doi "https://doi.org/10.1167/iovs.10-5637" @default.
• W1978412174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3055748" @default.
• W1978412174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20574018" @default.
• W1978412174 hasPublicationYear "2010" @default.
• W1978412174 type Work @default.
• W1978412174 sameAs 1978412174 @default.
• W1978412174 citedByCount "101" @default.
• W1978412174 countsByYear W19784121742012 @default.
• W1978412174 countsByYear W19784121742013 @default.
• W1978412174 countsByYear W19784121742014 @default.
• W1978412174 countsByYear W19784121742015 @default.
• W1978412174 countsByYear W19784121742016 @default.
• W1978412174 countsByYear W19784121742017 @default.
• W1978412174 countsByYear W19784121742018 @default.
• W1978412174 countsByYear W19784121742019 @default.
• W1978412174 countsByYear W19784121742020 @default.
• W1978412174 countsByYear W19784121742021 @default.
• W1978412174 countsByYear W19784121742022 @default.
• W1978412174 countsByYear W19784121742023 @default.
• W1978412174 crossrefType "journal-article" @default.
• W1978412174 hasAuthorship W1978412174A5004857974 @default.
• W1978412174 hasAuthorship W1978412174A5010280456 @default.
• W1978412174 hasAuthorship W1978412174A5017028738 @default.
• W1978412174 hasAuthorship W1978412174A5020628503 @default.
• W1978412174 hasAuthorship W1978412174A5040200688 @default.
• W1978412174 hasAuthorship W1978412174A5041500763 @default.
• W1978412174 hasAuthorship W1978412174A5043372772 @default.
• W1978412174 hasAuthorship W1978412174A5066334310 @default.
• W1978412174 hasAuthorship W1978412174A5068302775 @default.
• W1978412174 hasAuthorship W1978412174A5090802305 @default.
• W1978412174 hasBestOaLocation W19784121742 @default.
• W1978412174 hasConcept C118487528 @default.
• W1978412174 hasConcept C126322002 @default.
• W1978412174 hasConcept C197934379 @default.
• W1978412174 hasConcept C2776391266 @default.
• W1978412174 hasConcept C2776403814 @default.
• W1978412174 hasConcept C2778257484 @default.
• W1978412174 hasConcept C2779093074 @default.
• W1978412174 hasConcept C2779100554 @default.
• W1978412174 hasConcept C2781172350 @default.
• W1978412174 hasConcept C535046627 @default.
• W1978412174 hasConcept C71924100 @default.
• W1978412174 hasConceptScore W1978412174C118487528 @default.
• W1978412174 hasConceptScore W1978412174C126322002 @default.
• W1978412174 hasConceptScore W1978412174C197934379 @default.

• next