FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978412429> ?p ?o ?g. }

• W1978412429 endingPage "58" @default.
• W1978412429 startingPage "51" @default.
• W1978412429 abstract "In this study, the cytoprotective effects of caffeine (CAF) and 8-(3-chlorostyryl)-caffeine (CSC), A2A receptor antagonists, were tested against 6-OHDA-induced cytotoxicity, in rat mesencephalic cells. Both drugs significantly increased the number of viable cells, after their exposure to 6-OHDA, as measured by the MTT assay. While nitrite levels in the cells were drastically increased by 6-OHDA, their concentrations were brought toward normality after CAF or CSC, indicating that both drugs block 6-OHDA-induced oxidative stress which leads to free radicals generation. A complete blockade of 6-OHDA-induced lipid peroxidation, considered as a major source of DNA damage, was observed after cells treatment with CAF or CSC. 6-OHDA decreased the number of normal cells while increasing the number of apoptotic cells. In the CAF plus 6-OHDA group, a significant recover in the number of viable cells and a decrease in the number of apoptotic cells were seen, as compared to the group treated with 6-OHDA alone. A similar effect was observed after cells exposure to CSC in the presence of 6-OHDA. Unexpectedly, while a significant lower number of activated microglia was observed after cells exposure to CAF plus 6-OHDA, this was not the case after cells exposure to CSC under the same conditions. While CAF lowered the percentage of reactive astrocytes increased by 6-OHDA, CSC presented no effect. The effects of these drugs were also examined on the releases of myeloperoxidase (MPO), an inflammatory marker, and lactate dehydrogenase (LDH), a marker for cytotoxicity, in human neutrophils, in vitro. CSC and CAF (0.1, 1 and 10 μg/ml) produced inhibitions of the MPO release from PMA-stimulated cells, ranging from 45 to 83%. In addition, CSC and CAF (5, 50 and 100 μg/ml) did not show any cytotoxicity in the range of concentrations used, as determined by the LDH assay. All together, our results showed a strong neuroptrotection afforded by caffeine or CSC, on rat mesencephalic cells exposed to 6-OHDA. Furthermore, CSC and caffeine actions, inhibiting MPO as well as LDH releases, would contribute to their possible benefit in the treatment of neurodegenerative diseases, including DP. These effects are partially due to the ability of these A2A antagonists to decrease the cells free radicals production and oxidative stress, that are major components of 6-OHDA-induced cytotoxicity." @default.
• W1978412429 created "2016-06-24" @default.
• W1978412429 creator A5004643750 @default.
• W1978412429 creator A5026304077 @default.
• W1978412429 creator A5033244127 @default.
• W1978412429 creator A5043347063 @default.
• W1978412429 creator A5050453479 @default.
• W1978412429 creator A5059602973 @default.
• W1978412429 creator A5062024796 @default.
• W1978412429 creator A5065679072 @default.
• W1978412429 creator A5083240142 @default.
• W1978412429 date "2010-01-01" @default.
• W1978412429 modified "2023-09-26" @default.
• W1978412429 title "Caffeine and CSC, adenosine A2A antagonists, offer neuroprotection against 6-OHDA-induced neurotoxicity in rat mesencephalic cells" @default.
• W1978412429 cites W149565960 @default.
• W1978412429 cites W1515108121 @default.
• W1978412429 cites W1538399032 @default.
• W1978412429 cites W1552558074 @default.
• W1978412429 cites W1592905469 @default.
• W1978412429 cites W1594281994 @default.
• W1978412429 cites W1599584901 @default.
• W1978412429 cites W1900066504 @default.
• W1978412429 cites W1946523045 @default.
• W1978412429 cites W1968716671 @default.
• W1978412429 cites W1971289546 @default.
• W1978412429 cites W1972108431 @default.
• W1978412429 cites W1989720567 @default.
• W1978412429 cites W1990872391 @default.
• W1978412429 cites W1999869745 @default.
• W1978412429 cites W2005611046 @default.
• W1978412429 cites W2008871586 @default.
• W1978412429 cites W2010405290 @default.
• W1978412429 cites W2013139563 @default.
• W1978412429 cites W2016036161 @default.
• W1978412429 cites W2018019777 @default.
• W1978412429 cites W2026475932 @default.
• W1978412429 cites W2027592192 @default.
• W1978412429 cites W2030108063 @default.
• W1978412429 cites W2034588648 @default.
• W1978412429 cites W2040252933 @default.
• W1978412429 cites W2042095401 @default.
• W1978412429 cites W2046663117 @default.
• W1978412429 cites W2047968402 @default.
• W1978412429 cites W2050968935 @default.
• W1978412429 cites W2054555865 @default.
• W1978412429 cites W2057451803 @default.
• W1978412429 cites W2060183829 @default.
• W1978412429 cites W2068276747 @default.
• W1978412429 cites W2073352062 @default.
• W1978412429 cites W2076869894 @default.
• W1978412429 cites W2077045139 @default.
• W1978412429 cites W2079283237 @default.
• W1978412429 cites W2080581682 @default.
• W1978412429 cites W2086340148 @default.
• W1978412429 cites W2088277236 @default.
• W1978412429 cites W2088362408 @default.
• W1978412429 cites W2092736992 @default.
• W1978412429 cites W2111464898 @default.
• W1978412429 cites W2111597060 @default.
• W1978412429 cites W2127823171 @default.
• W1978412429 cites W2131371182 @default.
• W1978412429 cites W2135250775 @default.
• W1978412429 cites W2136365746 @default.
• W1978412429 cites W2140283306 @default.
• W1978412429 cites W2168819285 @default.
• W1978412429 doi "https://doi.org/10.1016/j.neuint.2009.09.001" @default.
• W1978412429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19782116" @default.
• W1978412429 hasPublicationYear "2010" @default.
• W1978412429 type Work @default.
• W1978412429 sameAs 1978412429 @default.
• W1978412429 citedByCount "43" @default.
• W1978412429 countsByYear W19784124292012 @default.
• W1978412429 countsByYear W19784124292013 @default.
• W1978412429 countsByYear W19784124292014 @default.
• W1978412429 countsByYear W19784124292016 @default.
• W1978412429 countsByYear W19784124292017 @default.
• W1978412429 countsByYear W19784124292018 @default.
• W1978412429 countsByYear W19784124292019 @default.
• W1978412429 countsByYear W19784124292020 @default.
• W1978412429 countsByYear W19784124292021 @default.
• W1978412429 countsByYear W19784124292022 @default.
• W1978412429 countsByYear W19784124292023 @default.
• W1978412429 crossrefType "journal-article" @default.
• W1978412429 hasAuthorship W1978412429A5004643750 @default.
• W1978412429 hasAuthorship W1978412429A5026304077 @default.
• W1978412429 hasAuthorship W1978412429A5033244127 @default.
• W1978412429 hasAuthorship W1978412429A5043347063 @default.
• W1978412429 hasAuthorship W1978412429A5050453479 @default.
• W1978412429 hasAuthorship W1978412429A5059602973 @default.
• W1978412429 hasAuthorship W1978412429A5062024796 @default.
• W1978412429 hasAuthorship W1978412429A5065679072 @default.
• W1978412429 hasAuthorship W1978412429A5083240142 @default.
• W1978412429 hasConcept C109316439 @default.
• W1978412429 hasConcept C178790620 @default.
• W1978412429 hasConcept C181199279 @default.
• W1978412429 hasConcept C185592680 @default.
• W1978412429 hasConcept C202751555 @default.
• W1978412429 hasConcept C25498285 @default.

• next