FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978430010> ?p ?o ?g. }

• W1978430010 endingPage "7632" @default.
• W1978430010 startingPage "7629" @default.
• W1978430010 abstract "Directed mutagenesis was used to probe the functions of Tyr-470 and Tyr-481 of Pseudomonas aeruginosa exotoxin A (ETA) with respect to cytotoxicity, ADP-ribosylation of elongation factor 2 (EF-2), and NAD-glycohydrolase activity. Both of these residues lie in the active site cleft, close to Glu-553, a residue believed to play a direct role in catalysis of ADP-ribosylation of EF-2. Substitution of Tyr-470 with Phe caused no change in any of these activities, thus eliminating the possibility that the phenolic hydroxyl group of Tyr-470 might be directly involved in catalysis. Mutation of Tyr-481 to Phe caused an approximately 10-fold reduction in NAD:EF-2 ADP-ribosyltransferase activity and cytotoxicity but no change in NAD-glycohydrolase activity. The latter mutation did not alter the KM of NAD in the NAD-glycohydrolase reaction, which suggests that the phenolic hydroxyl of Tyr-481 does not participate in NAD binding. We hypothesize that the phenolic hydroxyl of Tyr-481 may be involved in the interaction of the toxin with substrate EF-2." @default.
• W1978430010 created "2016-06-24" @default.
• W1978430010 creator A5072863421 @default.
• W1978430010 creator A5078561820 @default.
• W1978430010 date "1988-10-04" @default.
• W1978430010 modified "2023-10-12" @default.
• W1978430010 title "Pseudomonas aeruginosa exotoxin A: effects of mutating tyrosine-470 and tyrosine-481 to phenylalanine" @default.
• W1978430010 cites W1501027970 @default.
• W1978430010 cites W1521798347 @default.
• W1978430010 cites W1590641803 @default.
• W1978430010 cites W1998431483 @default.
• W1978430010 cites W2012939559 @default.
• W1978430010 cites W2042869569 @default.
• W1978430010 cites W2043148983 @default.
• W1978430010 cites W2072767834 @default.
• W1978430010 cites W2075485926 @default.
• W1978430010 cites W2094998867 @default.
• W1978430010 cites W2100837269 @default.
• W1978430010 cites W2105924088 @default.
• W1978430010 cites W2128635872 @default.
• W1978430010 doi "https://doi.org/10.1021/bi00420a009" @default.
• W1978430010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2849995" @default.
• W1978430010 hasPublicationYear "1988" @default.
• W1978430010 type Work @default.
• W1978430010 sameAs 1978430010 @default.
• W1978430010 citedByCount "33" @default.
• W1978430010 countsByYear W19784300102017 @default.
• W1978430010 crossrefType "journal-article" @default.
• W1978430010 hasAuthorship W1978430010A5072863421 @default.
• W1978430010 hasAuthorship W1978430010A5078561820 @default.
• W1978430010 hasConcept C103408237 @default.
• W1978430010 hasConcept C104317684 @default.
• W1978430010 hasConcept C109316439 @default.
• W1978430010 hasConcept C139124968 @default.
• W1978430010 hasConcept C143065580 @default.
• W1978430010 hasConcept C16318435 @default.
• W1978430010 hasConcept C181199279 @default.
• W1978430010 hasConcept C182179738 @default.
• W1978430010 hasConcept C185592680 @default.
• W1978430010 hasConcept C202751555 @default.
• W1978430010 hasConcept C2776165026 @default.
• W1978430010 hasConcept C2777431362 @default.
• W1978430010 hasConcept C2777637488 @default.
• W1978430010 hasConcept C2781338088 @default.
• W1978430010 hasConcept C45510557 @default.
• W1978430010 hasConcept C501734568 @default.
• W1978430010 hasConcept C515207424 @default.
• W1978430010 hasConcept C523546767 @default.
• W1978430010 hasConcept C54355233 @default.
• W1978430010 hasConcept C55493867 @default.
• W1978430010 hasConcept C67705224 @default.
• W1978430010 hasConcept C71240020 @default.
• W1978430010 hasConcept C75520062 @default.
• W1978430010 hasConcept C86803240 @default.
• W1978430010 hasConcept C88478588 @default.
• W1978430010 hasConceptScore W1978430010C103408237 @default.
• W1978430010 hasConceptScore W1978430010C104317684 @default.
• W1978430010 hasConceptScore W1978430010C109316439 @default.
• W1978430010 hasConceptScore W1978430010C139124968 @default.
• W1978430010 hasConceptScore W1978430010C143065580 @default.
• W1978430010 hasConceptScore W1978430010C16318435 @default.
• W1978430010 hasConceptScore W1978430010C181199279 @default.
• W1978430010 hasConceptScore W1978430010C182179738 @default.
• W1978430010 hasConceptScore W1978430010C185592680 @default.
• W1978430010 hasConceptScore W1978430010C202751555 @default.
• W1978430010 hasConceptScore W1978430010C2776165026 @default.
• W1978430010 hasConceptScore W1978430010C2777431362 @default.
• W1978430010 hasConceptScore W1978430010C2777637488 @default.
• W1978430010 hasConceptScore W1978430010C2781338088 @default.
• W1978430010 hasConceptScore W1978430010C45510557 @default.
• W1978430010 hasConceptScore W1978430010C501734568 @default.
• W1978430010 hasConceptScore W1978430010C515207424 @default.
• W1978430010 hasConceptScore W1978430010C523546767 @default.
• W1978430010 hasConceptScore W1978430010C54355233 @default.
• W1978430010 hasConceptScore W1978430010C55493867 @default.
• W1978430010 hasConceptScore W1978430010C67705224 @default.
• W1978430010 hasConceptScore W1978430010C71240020 @default.
• W1978430010 hasConceptScore W1978430010C75520062 @default.
• W1978430010 hasConceptScore W1978430010C86803240 @default.
• W1978430010 hasConceptScore W1978430010C88478588 @default.
• W1978430010 hasIssue "20" @default.
• W1978430010 hasLocation W19784300101 @default.
• W1978430010 hasLocation W19784300102 @default.
• W1978430010 hasOpenAccess W1978430010 @default.
• W1978430010 hasPrimaryLocation W19784300101 @default.
• W1978430010 hasRelatedWork W1576858785 @default.
• W1978430010 hasRelatedWork W1972656981 @default.
• W1978430010 hasRelatedWork W2021072729 @default.
• W1978430010 hasRelatedWork W2027866389 @default.
• W1978430010 hasRelatedWork W2072767834 @default.
• W1978430010 hasRelatedWork W2077897771 @default.
• W1978430010 hasRelatedWork W2140685577 @default.
• W1978430010 hasRelatedWork W2342819311 @default.
• W1978430010 hasRelatedWork W300491742 @default.
• W1978430010 hasRelatedWork W971408765 @default.
• W1978430010 hasVolume "27" @default.
• W1978430010 isParatext "false" @default.
• W1978430010 isRetracted "false" @default.

• next