Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978440273> ?p ?o ?g. }
- W1978440273 endingPage "320" @default.
- W1978440273 startingPage "311" @default.
- W1978440273 abstract "It is unclear, whether pediatric patients with type 1 diabetes (T1DM) show immunological alterations typically found in autoimmune conditions resembling immune dysfunction of the thymus, such as decrease of naïve T cells, lower T cell receptor excision circle (TREC) numbers, telomeric erosion, and diminished interleukin-7 (IL-7) levels. Furthermore, it is unknown, whether long-term therapy with insulin, a thymic growth factor, interferes with these changes. Therefore, the aim of this study was to analyze the quantity of the naïve T cell subset and its TREC content, relative telomere length (RTL) of naïve T cells, and peripheral IL-7 levels in patients with recent-onset T1DM (n = 5), long-standing T1DM (n = 33), and age-matched healthy donors (HD) (n = 37). In long-standing T1DM, TREC numbers/CD8+CD45RA+ T cells were enhanced (p < 0.01) compared to HD and correlated with disease duration (p < 0.02), an independent factor for increased thymic output (p < 0.01), and insulin dosage at blood withdrawal (p < 0.05). IL-7 serum levels were elevated in long-standing T1DM (p < 0.001) and positively correlated with TREC numbers (p < 0.01) and disease duration (p < 0.0001). RTLs in CD8+CD45RA+ T cells were significantly increased compared to HD (p < 0.02). Our data suggest that longterm insulin therapy may serve as a driving factor for thymic function and rejuvenation of the naïve T cell compartment. The ability of the immune system to reconstitute the naïve T cell compartment under well-adjusted insulin therapy may be of major importance for recognition of new antigens, response to vaccinations, and defense of infectious complications." @default.
- W1978440273 created "2016-06-24" @default.
- W1978440273 creator A5004298515 @default.
- W1978440273 creator A5006729888 @default.
- W1978440273 creator A5030991205 @default.
- W1978440273 creator A5050209368 @default.
- W1978440273 creator A5056490986 @default.
- W1978440273 creator A5060079840 @default.
- W1978440273 creator A5065127218 @default.
- W1978440273 creator A5069589060 @default.
- W1978440273 creator A5073326264 @default.
- W1978440273 creator A5086054614 @default.
- W1978440273 date "2009-10-01" @default.
- W1978440273 modified "2023-09-27" @default.
- W1978440273 title "Elevated Proportions of Recent Thymic Emigrants in Children and Adolescents with Type 1 Diabetes" @default.
- W1978440273 cites W101346465 @default.
- W1978440273 cites W1498259953 @default.
- W1978440273 cites W1501122454 @default.
- W1978440273 cites W1549784413 @default.
- W1978440273 cites W1580217007 @default.
- W1978440273 cites W1696746030 @default.
- W1978440273 cites W1888228645 @default.
- W1978440273 cites W1927236443 @default.
- W1978440273 cites W1972507682 @default.
- W1978440273 cites W1978564100 @default.
- W1978440273 cites W1990808205 @default.
- W1978440273 cites W2007932746 @default.
- W1978440273 cites W2015010814 @default.
- W1978440273 cites W2025551721 @default.
- W1978440273 cites W2026256588 @default.
- W1978440273 cites W2026340246 @default.
- W1978440273 cites W2028192388 @default.
- W1978440273 cites W2032346854 @default.
- W1978440273 cites W2032546353 @default.
- W1978440273 cites W2035569066 @default.
- W1978440273 cites W2039120803 @default.
- W1978440273 cites W2049627890 @default.
- W1978440273 cites W2062186122 @default.
- W1978440273 cites W2062395030 @default.
- W1978440273 cites W2063639905 @default.
- W1978440273 cites W2069147821 @default.
- W1978440273 cites W2073732452 @default.
- W1978440273 cites W2074185181 @default.
- W1978440273 cites W2076355973 @default.
- W1978440273 cites W2083738937 @default.
- W1978440273 cites W2087820476 @default.
- W1978440273 cites W2094916776 @default.
- W1978440273 cites W2096059629 @default.
- W1978440273 cites W2097278383 @default.
- W1978440273 cites W2098917229 @default.
- W1978440273 cites W2104318404 @default.
- W1978440273 cites W2109037058 @default.
- W1978440273 cites W2111193919 @default.
- W1978440273 cites W2138252614 @default.
- W1978440273 cites W2144729402 @default.
- W1978440273 cites W2160621707 @default.
- W1978440273 cites W2163597123 @default.
- W1978440273 cites W2336850667 @default.
- W1978440273 cites W4205321574 @default.
- W1978440273 cites W4243957445 @default.
- W1978440273 doi "https://doi.org/10.1089/rej.2009.0863" @default.
- W1978440273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19725773" @default.
- W1978440273 hasPublicationYear "2009" @default.
- W1978440273 type Work @default.
- W1978440273 sameAs 1978440273 @default.
- W1978440273 citedByCount "17" @default.
- W1978440273 countsByYear W19784402732012 @default.
- W1978440273 countsByYear W19784402732013 @default.
- W1978440273 countsByYear W19784402732014 @default.
- W1978440273 countsByYear W19784402732015 @default.
- W1978440273 countsByYear W19784402732016 @default.
- W1978440273 countsByYear W19784402732017 @default.
- W1978440273 countsByYear W19784402732019 @default.
- W1978440273 countsByYear W19784402732022 @default.
- W1978440273 crossrefType "journal-article" @default.
- W1978440273 hasAuthorship W1978440273A5004298515 @default.
- W1978440273 hasAuthorship W1978440273A5006729888 @default.
- W1978440273 hasAuthorship W1978440273A5030991205 @default.
- W1978440273 hasAuthorship W1978440273A5050209368 @default.
- W1978440273 hasAuthorship W1978440273A5056490986 @default.
- W1978440273 hasAuthorship W1978440273A5060079840 @default.
- W1978440273 hasAuthorship W1978440273A5065127218 @default.
- W1978440273 hasAuthorship W1978440273A5069589060 @default.
- W1978440273 hasAuthorship W1978440273A5073326264 @default.
- W1978440273 hasAuthorship W1978440273A5086054614 @default.
- W1978440273 hasConcept C126322002 @default.
- W1978440273 hasConcept C134018914 @default.
- W1978440273 hasConcept C167672396 @default.
- W1978440273 hasConcept C170493617 @default.
- W1978440273 hasConcept C203014093 @default.
- W1978440273 hasConcept C2776090121 @default.
- W1978440273 hasConcept C2777180221 @default.
- W1978440273 hasConcept C2779075594 @default.
- W1978440273 hasConcept C2779134260 @default.
- W1978440273 hasConcept C2779306644 @default.
- W1978440273 hasConcept C2781232474 @default.
- W1978440273 hasConcept C555293320 @default.
- W1978440273 hasConcept C71924100 @default.