Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978441796> ?p ?o ?g. }
- W1978441796 endingPage "104" @default.
- W1978441796 startingPage "101" @default.
- W1978441796 abstract "Brain changes in response to nerve damage or cochlear trauma can generate pathological neural activity that is believed to be responsible for many types of chronic pain and tinnitus. Several studies have reported that the severity of chronic pain and tinnitus is correlated with the degree of map reorganization in somatosensory and auditory cortex, respectively. Direct electrical or transcranial magnetic stimulation of sensory cortex can temporarily disrupt these phantom sensations. However, there is as yet no direct evidence for a causal role of plasticity in the generation of pain or tinnitus. Here we report evidence that reversing the brain changes responsible can eliminate the perceptual impairment in an animal model of noise-induced tinnitus. Exposure to intense noise degrades the frequency tuning of auditory cortex neurons and increases cortical synchronization. Repeatedly pairing tones with brief pulses of vagus nerve stimulation completely eliminated the physiological and behavioural correlates of tinnitus in noise-exposed rats. These improvements persisted for weeks after the end of therapy. This method for restoring neural activity to normal may be applicable to a variety of neurological disorders." @default.
- W1978441796 created "2016-06-24" @default.
- W1978441796 creator A5003805355 @default.
- W1978441796 creator A5013924606 @default.
- W1978441796 creator A5014092439 @default.
- W1978441796 creator A5018432109 @default.
- W1978441796 creator A5019164186 @default.
- W1978441796 creator A5037463089 @default.
- W1978441796 creator A5087994040 @default.
- W1978441796 date "2011-01-12" @default.
- W1978441796 modified "2023-10-04" @default.
- W1978441796 title "Reversing pathological neural activity using targeted plasticity" @default.
- W1978441796 cites W1501988144 @default.
- W1978441796 cites W1528279717 @default.
- W1978441796 cites W1553093690 @default.
- W1978441796 cites W1592304224 @default.
- W1978441796 cites W1963981940 @default.
- W1978441796 cites W1970303222 @default.
- W1978441796 cites W1973458820 @default.
- W1978441796 cites W1973541193 @default.
- W1978441796 cites W1980404776 @default.
- W1978441796 cites W1985501510 @default.
- W1978441796 cites W1985946645 @default.
- W1978441796 cites W2001110658 @default.
- W1978441796 cites W2014034835 @default.
- W1978441796 cites W2017380981 @default.
- W1978441796 cites W2037667533 @default.
- W1978441796 cites W2061059800 @default.
- W1978441796 cites W2066389227 @default.
- W1978441796 cites W2068623475 @default.
- W1978441796 cites W2068786656 @default.
- W1978441796 cites W2074477628 @default.
- W1978441796 cites W2075050776 @default.
- W1978441796 cites W2078790407 @default.
- W1978441796 cites W2084059718 @default.
- W1978441796 cites W2087445815 @default.
- W1978441796 cites W2090033371 @default.
- W1978441796 cites W2093545276 @default.
- W1978441796 cites W2131479747 @default.
- W1978441796 cites W2135640921 @default.
- W1978441796 cites W2140588294 @default.
- W1978441796 cites W2151491584 @default.
- W1978441796 cites W2156169729 @default.
- W1978441796 cites W2208494806 @default.
- W1978441796 cites W4249561229 @default.
- W1978441796 doi "https://doi.org/10.1038/nature09656" @default.
- W1978441796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3295231" @default.
- W1978441796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21228773" @default.
- W1978441796 hasPublicationYear "2011" @default.
- W1978441796 type Work @default.
- W1978441796 sameAs 1978441796 @default.
- W1978441796 citedByCount "532" @default.
- W1978441796 countsByYear W19784417962012 @default.
- W1978441796 countsByYear W19784417962013 @default.
- W1978441796 countsByYear W19784417962014 @default.
- W1978441796 countsByYear W19784417962015 @default.
- W1978441796 countsByYear W19784417962016 @default.
- W1978441796 countsByYear W19784417962017 @default.
- W1978441796 countsByYear W19784417962018 @default.
- W1978441796 countsByYear W19784417962019 @default.
- W1978441796 countsByYear W19784417962020 @default.
- W1978441796 countsByYear W19784417962021 @default.
- W1978441796 countsByYear W19784417962022 @default.
- W1978441796 countsByYear W19784417962023 @default.
- W1978441796 crossrefType "journal-article" @default.
- W1978441796 hasAuthorship W1978441796A5003805355 @default.
- W1978441796 hasAuthorship W1978441796A5013924606 @default.
- W1978441796 hasAuthorship W1978441796A5014092439 @default.
- W1978441796 hasAuthorship W1978441796A5018432109 @default.
- W1978441796 hasAuthorship W1978441796A5019164186 @default.
- W1978441796 hasAuthorship W1978441796A5037463089 @default.
- W1978441796 hasAuthorship W1978441796A5087994040 @default.
- W1978441796 hasBestOaLocation W19784417962 @default.
- W1978441796 hasConcept C15744967 @default.
- W1978441796 hasConcept C169760540 @default.
- W1978441796 hasConcept C172497186 @default.
- W1978441796 hasConcept C24998067 @default.
- W1978441796 hasConcept C2776992516 @default.
- W1978441796 hasConcept C2778581513 @default.
- W1978441796 hasConcept C2780087125 @default.
- W1978441796 hasConcept C2780297895 @default.
- W1978441796 hasConcept C2781404750 @default.
- W1978441796 hasConcept C47611674 @default.
- W1978441796 hasConcept C548259974 @default.
- W1978441796 hasConcept C71924100 @default.
- W1978441796 hasConcept C94487597 @default.
- W1978441796 hasConceptScore W1978441796C15744967 @default.
- W1978441796 hasConceptScore W1978441796C169760540 @default.
- W1978441796 hasConceptScore W1978441796C172497186 @default.
- W1978441796 hasConceptScore W1978441796C24998067 @default.
- W1978441796 hasConceptScore W1978441796C2776992516 @default.
- W1978441796 hasConceptScore W1978441796C2778581513 @default.
- W1978441796 hasConceptScore W1978441796C2780087125 @default.
- W1978441796 hasConceptScore W1978441796C2780297895 @default.
- W1978441796 hasConceptScore W1978441796C2781404750 @default.
- W1978441796 hasConceptScore W1978441796C47611674 @default.
- W1978441796 hasConceptScore W1978441796C548259974 @default.
- W1978441796 hasConceptScore W1978441796C71924100 @default.