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- W1978442649 abstract "The inhibition of mitochondrial succinate oxidase by four classes of uncouplers of oxidative phosphorylation (nitrophenols, dicumarol, substituted benzimidazoles, and substituted phenylhydrazones of carbonyl cyanide) has been examined kinetically by Lineweaver-Burke plots. All of these uncouplers inhibit by increasing the apparent Km for succinate with no effect on maximal rate of oxidation (Vm). The uncoupler concentration dependence of the inhibition varies from less than first power for the carbonyl cyanide derivatives to second power for dicumarol. When the inhibitory effects of the uncouplers were compared on a per unit of uncoupler activity basis, they were found to differ by at least a factor of 10." @default.
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- W1978442649 date "1967-01-01" @default.
- W1978442649 modified "2023-09-25" @default.
- W1978442649 title "Inhibition of mitochondrial respiration by uncouplers of oxidative phosphorylation" @default.
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- W1978442649 doi "https://doi.org/10.1016/0003-9861(67)90478-x" @default.
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