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• W1978447516 abstract "Several thieno[2,3-d]pyrimidinediones have been synthesized and examined for antibacterial activity against a range of gram-positive and gram-negative pathogens. Two compounds displayed potent activity (2-16 mg/L) against multi-drug resistant gram-positive organisms, including methicillin resistant, vancomycin-intermediate, vancomycin-resistant Staphylococcus aureus (MRSA, VISA, VRSA) and vancomycin-resistant enterococci (VRE). Only one of these agents possessed moderate activity (16-32 mg/L) against gram-negative strains. An examination of the cytotoxicity of these agents revealed that they displayed low toxicity (40-50 mg/L) against mammalian cells and very low hemolytic activity (2-7%). Taken together, these studies suggest that thieno[2,3-d]pyrimidinediones are interesting scaffolds for the development of novel gram-positive antibacterial agents." @default.
• W1978447516 created "2016-06-24" @default.
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• W1978447516 date "2012-05-01" @default.
• W1978447516 modified "2023-09-27" @default.
• W1978447516 title "Thieno[2,3-d]pyrimidinedione derivatives as antibacterial agents" @default.
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• W1978447516 doi "https://doi.org/10.1016/j.ejmech.2012.02.035" @default.
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