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- W1978449116 abstract "Compared to (+)-pseudococaine, (−)-cocaine was 20 times more potent in inhibiting uptake of 3H-norepinephrine (3HNE) by cortical synaptosomes and 66 times more potent with respect to 3H-dopamine (3HDA) uptake by striatal synaptosomes. Although the tropacocaine isomers were equipotent as inhibitors of 3HNE uptake in the cortex, tropacocaine was 3.9 times more potent as an inhibitor of 3HDa uptake in the striatum than pseudotropococaine. A major known cocaine metabolite, benzoylecgonine failed to inhibit the accumulation of 3HNE and 3HDA by synaptosomes from the cortex and striatum, respectively. The implications of these findings in relation to the motor stimulation seen with (−)-cocaine, (+)-pseudococaine and benzoylecgonine in rats are discussed." @default.
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- W1978449116 date "1977-10-01" @default.
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- W1978449116 title "The isomers of cocaine and tropacocaine: Effect on 3H-catecholamine uptake by rat brain synaptosomes" @default.
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- W1978449116 doi "https://doi.org/10.1016/0024-3205(77)90110-2" @default.
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