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• W1978453417 endingPage "2005" @default.
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• W1978453417 abstract "Osteoclasts are highly specialized cells that resorb bone, and their abnormal activity is implicated in a variety of human bone diseases. In neoplastic bone metastasis, the bone destruction caused by osteoclasts is not only associated with the formation and progression of metastatic lesions, but also could contribute to frequent complications such as severe pain and pathological fractures, which greatly diminish the quality of life of patients. Bisphosphonates, potent antiresorptive drugs, have been shown to have efficacy for treating bone metastases in many types of cancer, and the development of various molecularly targeted agents is currently proceeding. Thus, inhibition of osteoclast function is now established as an important treatment strategy for bony metastases. This review focuses on promising small molecules that disrupt osteoclast function and introduces our chemical/biological approach for identifying osteoclast‐targeting small molecular inhibitors. ( Cancer Sci 2009)" @default.
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• W1978453417 date "2009-10-11" @default.
• W1978453417 modified "2023-10-17" @default.
• W1978453417 title "Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases" @default.
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• W1978453417 doi "https://doi.org/10.1111/j.1349-7006.2009.01294.x" @default.
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