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• W1978456988 endingPage "255" @default.
• W1978456988 startingPage "242" @default.
• W1978456988 abstract "Interactions between brain alpha2- and beta-adrenoceptors are of interest in physiological (aging) and pathological (major depression) processes involving both receptors. In this study, total beta-adrenoceptors and beta1/2-subtypes were quantitated in postmortem human brains to investigate their relationships with alpha2A-adrenoceptors and specific G proteins during the process of aging and in brains of suicide victims. Analysis of [3H]CGP12177 binding, in the presence of CGP20712A (beta1-antagonist), indicated that the predominant beta-adrenoceptor in the frontal cortex is the beta1-subtype (65-75%). The density of total beta- (r=-0.60, n=44) or beta1-adrenoceptors (r=-0.78, n=22), but not the beta2-subtype, declined with aging (3-80 years). The density of total beta- or beta1-adrenoceptors, but not the beta2-subtype, correlated with the number of alpha2-adrenoceptors quantitated in the same brains with the agonist [3H]UK14304 (r=0.71-0.81) or the antagonist [3H]RX821002 (r=0.61-0.66). Interestingly, the ratios alpha2/beta- or alpha2/beta1-adrenoceptors did not correlate with the age of the subject at death, indicating that the proportion of alpha2/beta-adrenoceptors in brain remains rather constant during the process of aging. The density of beta-adrenoceptors correlated with the immunodensity of G(alpha)s (r=0.55) and Gbeta (r=0.61) proteins, and that of alpha2-adrenoceptors with those of G(alpha)i1/2 (r=0.88) and Gbeta (r=0.65). In brains of suicides, compared to controls, the ratio between alpha2- and beta- or beta1-adrenoceptors (alpha2-full agonist sites/beta-sites) was greater (1.3- to 2.0-fold; P<0.05). The results demonstrate a close interdependence between brain alpha2- and beta-adrenoceptors during aging, and in brains of suicides. The quantitation of the alpha2A/beta-adrenoceptor ratio could represent a relevant neurochemical index in the study of brain pathologies in which both receptors are involved." @default.
• W1978456988 created "2016-06-24" @default.
• W1978456988 creator A5044317538 @default.
• W1978456988 creator A5069864591 @default.
• W1978456988 creator A5090943326 @default.
• W1978456988 date "2001-04-01" @default.
• W1978456988 modified "2023-10-18" @default.
• W1978456988 title "Relationships between β- and α2-adrenoceptors and G coupling proteins in the human brain: effects of age and suicide" @default.
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• W1978456988 doi "https://doi.org/10.1016/s0006-8993(01)02190-4" @default.
• W1978456988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11306010" @default.
• W1978456988 hasPublicationYear "2001" @default.
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