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• W1978459069 abstract "ISEE-166 Introduction: Body burden measures may act as markers for long-term exposure if biomarkers can be found with sufficiently long half lives in the human body. We tested the hypothesis that women with long term residence close to an industrial complex have a higher body burden and a distinct pattern of dioxins, furans (PCDD/F) and polychlorinated biphenyls (PCBs). Method Design: Observational study of 40 women living near (0.1–2.7 km) and distant (5–40 km) from an industrial complex on Teesside, UK. Subjects and setting: Subjects were recruited from participants in a case-control study of residential exposure to air pollution and lung cancer. Residences were assigned to exposure zones: A=near, B=intermediate, C=distant from industry; informed by land-use surveys, dispersion modelling and monitoring. We recruited 20 women from zone A (10 cases and 10 controls) and 20 from zone C (10 cases and 10 controls) sequentially between Jan 00 and Dec 03. Women with weight loss of ≥3.5 kg over last 3 months or who had lived for less than 20 years consecutively in their current zone were excluded. Data collection: Information on: occupational exposure; residential history; current and past consumption of local animal and vegetable produce; breast feeding; current and typical diet; and self-reported height and weight was collected at interview. Whole blood was analysed for PCDD/F and PCBs. Results: Mean age was 62.5 years for Zone A participants and 65.3 years in zone C. Mean BMI, and lifelong dietary patterns were similar except Zone A participants had slightly higher consumption of fish and slightly lower consumption of meat.Table 1: Body burden of PCDD/F and selected PCBs in Zones A and C in ng/kg lipid base.We found no significant difference in body burden for any of the indicators between zones A and C participants. All congener patterns were consistent with an urban background pattern. In multivariate linear regression no significant differences were found in any body burden measures between participants form zones A and C, after adjusting for potential confounders. The only consistently significant predictor of PCDD/F and PCB body burden was age. Discussion: This was a population based study with much detail on confounding information. The findings suggest that the intake of PCDD/F and PCB through background food consumption were such a dominant source of exposure that impacts from local point sources were undetectable. Body burden of these biomarkers were not a useful indicator for long term residential exposure in this setting." @default.
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• W1978459069 date "2004-07-01" @default.
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• W1978459069 title "CAN DIOXIN BODY BURDEN DATA BE USED TO ESTIMATE LONG TERM RESIDENTIAL EXPOSURE TO INDUSTRIAL POLLUTION?" @default.
• W1978459069 doi "https://doi.org/10.1097/00001648-200407000-00189" @default.
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