FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978464392> ?p ?o ?g. }

• W1978464392 endingPage "70" @default.
• W1978464392 startingPage "61" @default.
• W1978464392 abstract "Background: Uptake of non-transferrin-bound iron by the liver is important as a clearance mechanism in iron overload. In contrast to physiological uptake via receptor-mediated endocytosis of transferrin, no regulatory mechanisms for this process are known. This study compares the influence of long-term and shortterm depletion and loading of hepatocytes with iron on the uptake of non-transferrin bound iron, its affinity, specificity and the interaction with the transferrinmediated pathways. Methods: Rats were fed iron-deficient, normal and 3,5,5-trimethylhexanoyl-ferrocene-containing diets to obtain livers with the corresponding desired status and the hepatocytes from these livers were used for transport studies. Hepatocytes from normal rats were depleted or loaded with iron by short-term treatment with desferrioxamine or ferric ammonium citrate, respectively. Uptake of non-transferrin bound iron was assayed from ferric citrate and from ferric diethylene triammine pentaacetate. Results: Uptake of non-transferrin-bound iron in hepatocytes could be seen as consisting of a high-affinity (Km=600 nM) and a low-affinity component. Whereas in normal and in iron-starved rats the high-affinity component was more prominent, it disappeared altogether in hepatocytes from rats with iron overload resulting from prolonged feeding with TMH-ferrocene-enriched diet. Overloading also led to loss of inhibition by diferric transferrin, which occured in starved as well as normal cells. In contrast, shortterm iron-depletion of isolated hepatocytes with desferrioxamine had only a weak stimulatory effect, whereas treatment with ferric ammonium citrate strongly increased the uptake rates. However, the inhibition by diferric transferrin also disappeared. In both cases, uptake of non-transferrin bound iron was inhibited by apotransferrin. Conclusions: Non-transferrin bound iron uptake in liver cells is apparently regulated by the iron status of the liver. The mode of response to iron loading depends on the method of loading in terms of time course and the form of iron used. It cannot be explained by the behavior of the iron regulatory protein, and it is complex, seeming to involve more than one transport system." @default.
• W1978464392 created "2016-06-24" @default.
• W1978464392 creator A5005785494 @default.
• W1978464392 creator A5016469647 @default.
• W1978464392 creator A5032206643 @default.
• W1978464392 creator A5062348499 @default.
• W1978464392 date "1999-07-01" @default.
• W1978464392 modified "2023-10-17" @default.
• W1978464392 title "Differential response of non-transferrin bound iron uptake in rat liver cells on long-term and short-term treatment with iron" @default.
• W1978464392 cites W1490154674 @default.
• W1978464392 cites W1496473441 @default.
• W1978464392 cites W1537207127 @default.
• W1978464392 cites W1549632498 @default.
• W1978464392 cites W1550693195 @default.
• W1978464392 cites W1557248110 @default.
• W1978464392 cites W1568628619 @default.
• W1978464392 cites W1585426774 @default.
• W1978464392 cites W1587837383 @default.
• W1978464392 cites W1595921363 @default.
• W1978464392 cites W1603628987 @default.
• W1978464392 cites W1883620080 @default.
• W1978464392 cites W1979041463 @default.
• W1978464392 cites W1998076544 @default.
• W1978464392 cites W2001818765 @default.
• W1978464392 cites W2005687534 @default.
• W1978464392 cites W2007061375 @default.
• W1978464392 cites W2008436432 @default.
• W1978464392 cites W2022591197 @default.
• W1978464392 cites W2024373128 @default.
• W1978464392 cites W2028572503 @default.
• W1978464392 cites W2039857448 @default.
• W1978464392 cites W2048464063 @default.
• W1978464392 cites W2063468135 @default.
• W1978464392 cites W2066743380 @default.
• W1978464392 cites W2070236309 @default.
• W1978464392 cites W2072383111 @default.
• W1978464392 cites W2072940532 @default.
• W1978464392 cites W2074379230 @default.
• W1978464392 cites W2081967521 @default.
• W1978464392 cites W2086168903 @default.
• W1978464392 cites W2086206191 @default.
• W1978464392 cites W2088452431 @default.
• W1978464392 cites W2091806624 @default.
• W1978464392 cites W2142414948 @default.
• W1978464392 cites W2145275333 @default.
• W1978464392 cites W2158823872 @default.
• W1978464392 cites W2165118830 @default.
• W1978464392 cites W2981136861 @default.
• W1978464392 cites W4240961027 @default.
• W1978464392 cites W4251819674 @default.
• W1978464392 cites W4293247451 @default.
• W1978464392 doi "https://doi.org/10.1016/s0168-8278(99)80164-0" @default.
• W1978464392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10424284" @default.
• W1978464392 hasPublicationYear "1999" @default.
• W1978464392 type Work @default.
• W1978464392 sameAs 1978464392 @default.
• W1978464392 citedByCount "19" @default.
• W1978464392 countsByYear W19784643922012 @default.
• W1978464392 countsByYear W19784643922013 @default.
• W1978464392 countsByYear W19784643922017 @default.
• W1978464392 countsByYear W19784643922019 @default.
• W1978464392 crossrefType "journal-article" @default.
• W1978464392 hasAuthorship W1978464392A5005785494 @default.
• W1978464392 hasAuthorship W1978464392A5016469647 @default.
• W1978464392 hasAuthorship W1978464392A5032206643 @default.
• W1978464392 hasAuthorship W1978464392A5062348499 @default.
• W1978464392 hasConcept C126322002 @default.
• W1978464392 hasConcept C134018914 @default.
• W1978464392 hasConcept C170493617 @default.
• W1978464392 hasConcept C179104552 @default.
• W1978464392 hasConcept C185592680 @default.
• W1978464392 hasConcept C202751555 @default.
• W1978464392 hasConcept C22814914 @default.
• W1978464392 hasConcept C2776200302 @default.
• W1978464392 hasConcept C2776590208 @default.
• W1978464392 hasConcept C2780534640 @default.
• W1978464392 hasConcept C28005876 @default.
• W1978464392 hasConcept C32264632 @default.
• W1978464392 hasConcept C55493867 @default.
• W1978464392 hasConcept C62231903 @default.
• W1978464392 hasConcept C71924100 @default.
• W1978464392 hasConcept C86803240 @default.
• W1978464392 hasConceptScore W1978464392C126322002 @default.
• W1978464392 hasConceptScore W1978464392C134018914 @default.
• W1978464392 hasConceptScore W1978464392C170493617 @default.
• W1978464392 hasConceptScore W1978464392C179104552 @default.
• W1978464392 hasConceptScore W1978464392C185592680 @default.
• W1978464392 hasConceptScore W1978464392C202751555 @default.
• W1978464392 hasConceptScore W1978464392C22814914 @default.
• W1978464392 hasConceptScore W1978464392C2776200302 @default.
• W1978464392 hasConceptScore W1978464392C2776590208 @default.
• W1978464392 hasConceptScore W1978464392C2780534640 @default.
• W1978464392 hasConceptScore W1978464392C28005876 @default.
• W1978464392 hasConceptScore W1978464392C32264632 @default.
• W1978464392 hasConceptScore W1978464392C55493867 @default.
• W1978464392 hasConceptScore W1978464392C62231903 @default.
• W1978464392 hasConceptScore W1978464392C71924100 @default.
• W1978464392 hasConceptScore W1978464392C86803240 @default.

• next