FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978470894> ?p ?o ?g. }

• W1978470894 endingPage "638" @default.
• W1978470894 startingPage "628" @default.
• W1978470894 abstract "The close homolog of the adhesion molecule L1 (CHL1) is important during CNS development, but a study with CHL1 knockout mice showed greater functional recovery after spinal cord injury (SCI) in its absence. We investigated CHL1 expression from 1 to 28 days after clinically relevant contusive SCI in Sprague-Dawley rats. Western blot analysis showed that CHL1 expression was significantly up-regulated at day 1 and further increased over 4 weeks after SCI. Immunohistochemistry of tissue sections showed that CHL1 in the intact spinal cord was expressed at low levels. By 1 day and through 4 weeks after SCI, CHL1 became highly expressed in NG2+ cells. Hypertrophic GFAP+ astrocytes also expressed CHL1 by 1 week after injury. The increase in CHL1 protein paralleled that of NG2 in the first week and GFAP between 1 and 4 weeks after injury. At 4 weeks, NG2+/CHL1+ cells and GFAP+/CHL1+ astrocytes were concentrated at the boundary between residual spinal cord tissue and the central lesion. NF200+ spinal cord axons approached but did not penetrate this boundary. In contrast, CHL1+ cells in the central lesion at 1 week and later colabeled with p75 and NG2 and were chronically associated with many NF200+ axons, presumably axons that had sprouted in association with CHL1+ Schwann cells infiltrating the cord after contusion. Thus, our study demonstrates up-regulation of CHL1 in multiple cell types and locations in a rat model of contusion injury and suggests that this molecule may be involved both in inhibition of axonal regeneration and in recovery processes after SCI. © 2011 Wiley-Liss, Inc." @default.
• W1978470894 created "2016-06-24" @default.
• W1978470894 creator A5035974662 @default.
• W1978470894 creator A5044230815 @default.
• W1978470894 creator A5073753234 @default.
• W1978470894 creator A5085970807 @default.
• W1978470894 creator A5088841044 @default.
• W1978470894 date "2011-02-17" @default.
• W1978470894 modified "2023-10-09" @default.
• W1978470894 title "Increased expression of the close homolog of the adhesion molecule l1 in different cell types over time after rat spinal cord contusion" @default.
• W1978470894 cites W1491124395 @default.
• W1978470894 cites W1551441210 @default.
• W1978470894 cites W1566509581 @default.
• W1978470894 cites W1585651720 @default.
• W1978470894 cites W1760881456 @default.
• W1978470894 cites W176748268 @default.
• W1978470894 cites W1822650859 @default.
• W1978470894 cites W1963533143 @default.
• W1978470894 cites W1965486404 @default.
• W1978470894 cites W1966708171 @default.
• W1978470894 cites W1968514746 @default.
• W1978470894 cites W1971675257 @default.
• W1978470894 cites W1972553563 @default.
• W1978470894 cites W1972654114 @default.
• W1978470894 cites W1975212239 @default.
• W1978470894 cites W1988042413 @default.
• W1978470894 cites W1988642487 @default.
• W1978470894 cites W1990964778 @default.
• W1978470894 cites W1994257911 @default.
• W1978470894 cites W2000663949 @default.
• W1978470894 cites W2004585963 @default.
• W1978470894 cites W2005207128 @default.
• W1978470894 cites W2007498641 @default.
• W1978470894 cites W2010771423 @default.
• W1978470894 cites W2012898904 @default.
• W1978470894 cites W2013700695 @default.
• W1978470894 cites W2015748431 @default.
• W1978470894 cites W2023105628 @default.
• W1978470894 cites W2032304318 @default.
• W1978470894 cites W2033655341 @default.
• W1978470894 cites W2034844685 @default.
• W1978470894 cites W2036412167 @default.
• W1978470894 cites W2041549555 @default.
• W1978470894 cites W2047804432 @default.
• W1978470894 cites W2048117462 @default.
• W1978470894 cites W2054673543 @default.
• W1978470894 cites W2055479094 @default.
• W1978470894 cites W2060926979 @default.
• W1978470894 cites W2067575601 @default.
• W1978470894 cites W2072223083 @default.
• W1978470894 cites W2075041384 @default.
• W1978470894 cites W2092262146 @default.
• W1978470894 cites W2104968232 @default.
• W1978470894 cites W2126362648 @default.
• W1978470894 cites W2132918091 @default.
• W1978470894 cites W2132957996 @default.
• W1978470894 cites W2170645579 @default.
• W1978470894 doi "https://doi.org/10.1002/jnr.22598" @default.
• W1978470894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21337374" @default.
• W1978470894 hasPublicationYear "2011" @default.
• W1978470894 type Work @default.
• W1978470894 sameAs 1978470894 @default.
• W1978470894 citedByCount "7" @default.
• W1978470894 countsByYear W19784708942012 @default.
• W1978470894 countsByYear W19784708942013 @default.
• W1978470894 countsByYear W19784708942018 @default.
• W1978470894 crossrefType "journal-article" @default.
• W1978470894 hasAuthorship W1978470894A5035974662 @default.
• W1978470894 hasAuthorship W1978470894A5044230815 @default.
• W1978470894 hasAuthorship W1978470894A5073753234 @default.
• W1978470894 hasAuthorship W1978470894A5085970807 @default.
• W1978470894 hasAuthorship W1978470894A5088841044 @default.
• W1978470894 hasBestOaLocation W19784708941 @default.
• W1978470894 hasConcept C105702510 @default.
• W1978470894 hasConcept C122871604 @default.
• W1978470894 hasConcept C142724271 @default.
• W1978470894 hasConcept C1491633281 @default.
• W1978470894 hasConcept C16224149 @default.
• W1978470894 hasConcept C169760540 @default.
• W1978470894 hasConcept C204232928 @default.
• W1978470894 hasConcept C2777542381 @default.
• W1978470894 hasConcept C2777594495 @default.
• W1978470894 hasConcept C2778334475 @default.
• W1978470894 hasConcept C2780775167 @default.
• W1978470894 hasConcept C2781156865 @default.
• W1978470894 hasConcept C529278444 @default.
• W1978470894 hasConcept C54355233 @default.
• W1978470894 hasConcept C71924100 @default.
• W1978470894 hasConcept C85789140 @default.
• W1978470894 hasConcept C86803240 @default.
• W1978470894 hasConcept C95444343 @default.
• W1978470894 hasConceptScore W1978470894C105702510 @default.
• W1978470894 hasConceptScore W1978470894C122871604 @default.
• W1978470894 hasConceptScore W1978470894C142724271 @default.
• W1978470894 hasConceptScore W1978470894C1491633281 @default.
• W1978470894 hasConceptScore W1978470894C16224149 @default.
• W1978470894 hasConceptScore W1978470894C169760540 @default.
• W1978470894 hasConceptScore W1978470894C204232928 @default.

• next