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- W1978473802 abstract "Fluid mechanical forces affect cardiac development. In the chick embryo, permanent obstruction of the right lateral vitelline vein reduces the mechanical load on the embryonic myocardium, which has been shown to induce a spectrum of outflow tract anomalies. Insight into the effects of this intervention on the mechanical function of the developing myocardium could contribute to a better understanding of the relationship between hemodynamics and cardiac morphogenesis. Cardiac pressure-volume relations enable a load-independent quantification of intrinsic ventricular systolic and diastolic properties. We determined ventricular function by pressure-volume loop analysis of in-ovo chick embryos (n = 15) at stage 24 (4.5 days of incubation) after venous obstruction at stage 17. Control embryos (n = 15) were used for comparison. End-systolic volume was significantly higher in clipped embryos (0.36 ± 0.02 µl vs. 0.29 ± 0.02 µl, p = 0.002). End-systolic pressure and end-diastolic pressure were also increased as compared to control animals (2.93 ± 0.07 mmHg vs. 2.70 ± 0.08 mmHg, p = 0.036 and 1.15 ± 0.06 mmHg vs. 0.82 ± 0.05 mmHg, p < 0.001). No significant differences were demonstrated for other baseline hemodynamic parameters. Analysis of pressure-volume relations showed a significantly lower end-systolic elastance in the clipped embryos (EES, slope of end-systolic pressure-volume relation: 2.91 ± 0.24 vs. 7.53 ± 0.66 mmHg/ml, p < 0.005) indicating reduced contractility. Diastolic stiffness was significantly increased in the clipped embryos (EED, slope of end-diastolic pressure-volume relation: 1.54ϕ ± 0.21 vs 0.60 ± 0.08, p < 0.005), indicating reduced compliance. We conclude that venous obstruction interferes with normal myocardial development resulting in impaired intrinsic systolic and diastolic ventricular function. These changes in ventricular function may precede morphological derangements observed in later developmental stages." @default.
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- W1978473802 date "2006-08-31" @default.
- W1978473802 modified "2023-09-27" @default.
- W1978473802 title "OP04.23: Impaired systolic and diastolic ventricular function after permanent extra-embryonic venous obstruction, a pressure-volume loop assessment in the stage-24 chick embryo" @default.
- W1978473802 doi "https://doi.org/10.1002/uog.3150" @default.
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