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- W1978474927 abstract "In this study, different molecular weight CM-chitosans were prepared and the effects on the growth and collagen secretion of normal skin fibroblasts and keloid fibroblasts were investigated in vitro. CM-chitosan promoted the proliferation of the normal skin fibroblast significantly but inhibited the proliferation of keloid fibroblast. The higher CM-chitosan concentration had a higher initial effect and the lower CM-chitosan concentration had a longer affecting time to the normal skin fibroblast. The lower molecular weight CM-chitosan had significant twofold activities. The CM-chitosan could reduce the ratio of type I/III collagen in keloid fibroblast by inhibiting the secretion of collagen type I; and had no effect on the secretion of types I and III collagen in the normal skin fibroblast." @default.
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- W1978474927 date "2002-12-01" @default.
- W1978474927 modified "2023-09-28" @default.
- W1978474927 title "The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts" @default.
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- W1978474927 doi "https://doi.org/10.1016/s0142-9612(02)00207-7" @default.
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