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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978478766> ?p ?o ?g. }

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• W1978478766 abstract "A variety of 2-heterocycle substituted 3-phenysulfonyl-5-chloroindoles were investigated as replacements for the 2-carboxamide functionality of the potent HIV-1 reverse transcriptase inhibitor L-737, 126. The 2-carboxamide series of compounds typified by L-737,126 have poor solubility. Replacement of the carboxamide moiety with a variety of heterocycles results in a series of potent enzyme inhibitors with equivalent ex vivo antiviral activity and improved physicochemical properties." @default.
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• W1978478766 date "1995-03-01" @default.
• W1978478766 modified "2023-10-10" @default.
• W1978478766 title "2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptase" @default.
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• W1978478766 doi "https://doi.org/10.1016/0960-894x(95)00059-3" @default.
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