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- W1978486300 abstract "Stress response mechanisms that modulate the dynamics of tRNA degradation and accumulation from the cytoplasm to the nucleus have been studied in yeast, the rat hepatoma and human cells. In the current study, we investigated tRNA degradation and accumulation in HeLa cells under various forms of stress. We found that initiator tRNA Met (tRNA(iMet)) was specifically degraded under heat stress. Two exonucleases, Xrn1 and Xrn2, are involved in the degradation of tRNA(iMet) in the cytoplasm and the nucleus, respectively. In addition to degradation, we observed accumulation of tRNA(iMet) in the nucleus. We also found that the mammalian target of rapamycin (mTOR), which regulates tRNA trafficking in yeast, is partially phosphorylated at Ser2448 in the presence of rapamycin and/or during heat stress. Our results suggest phosphorylation of mTOR may correlate with accumulation of tRNA(iMet) in heat-treated HeLa cells." @default.
- W1978486300 created "2016-06-24" @default.
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- W1978486300 date "2013-03-06" @default.
- W1978486300 modified "2023-10-17" @default.
- W1978486300 title "Degradation of initiator tRNA Met by Xrn1/2 via its accumulation in the nucleus of heat-treated HeLa cells" @default.
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- W1978486300 doi "https://doi.org/10.1093/nar/gkt153" @default.
- W1978486300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3632136" @default.
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