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• W1978489370 endingPage "646" @default.
• W1978489370 startingPage "637" @default.
• W1978489370 abstract "The heat shock proteins (hsps) are expressed in normal cells but their expression is enhanced by a number of different stresses including heat and ischaemia. They play important roles in chaperoning the folding of other proteins and in protein degradation. In the heart a number of studies have shown that prior induction of the hsps by a mild stress has a protective effect against a more severe stress. Moreover, over-expression of an individual hsp in cardiac cells in culture or in the intact heart of either transgenic animals or using virus vectors, also produces a protective effect, directly demonstrating the ability of the hsps to produce protection. These findings indicate the potential importance of developing procedures for elevating hsp expression in a safe and efficient manner in human individuals using either pharmacological or gene therapy procedures." @default.
• W1978489370 created "2016-06-24" @default.
• W1978489370 creator A5002956062 @default.
• W1978489370 date "2001-09-01" @default.
• W1978489370 modified "2023-10-01" @default.
• W1978489370 title "Heat shock proteins and cardiac protection" @default.
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• W1978489370 doi "https://doi.org/10.1016/s0008-6363(01)00354-6" @default.
• W1978489370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11530097" @default.
• W1978489370 hasPublicationYear "2001" @default.
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